Genomorphine

Base Information

• Chemical Name: Genomorphine
• CAS No.: 639-46-3
• Molecular Formula: C17H19 N O4
• Molecular Weight: 301.342
• Hs Code.: 2939190000
• DSSTox Substance ID: DTXSID00862342
• Mol file: 639-46-3.mol

Synonyms:Genomorphin;Genomorphine;Morphine oxide;DTXSID00862342;3-Methyl-3-oxo-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano-3lambda~5~-[1]benzofuro[3,2-e]isoquinoline-7,9-diol

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Genomorphine

Chemical Property:

• Melting Point: 222-225°C (dec.)
• Refractive Index: 1.5400 (estimate)
• Boiling Point: 442.47°C (rough estimate)
• PKA: pKa 4.82(50% aq EtOH) (Uncertain)
• Flash Point: 9℃
• PSA: 79.12000
• Density: 1.1222 (rough estimate)
• LogP: 1.16950
• Storage Temp.: Controlled Substance, -20°C Freezer
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 301.13140809
• Heavy Atom Count: 22
• Complexity: 539

Purity/Quality:

Safty Information:

• Pictogram(s): F,T
• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+]1(CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O)[O-]
• Uses: Morphine N-Oxide, is a metabolite of Morphine. A metabolite of Morphine. Controlled substance (M652290).

Technology Process of Genomorphine

There total 3 articles about Genomorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

MORPHIN (57-27-2) → morphine-N-oxide (639-46-3)

Guidance literature:

With dihydrogen peroxide; at 0 - 25 ℃; for 0.25h;

DOI:10.1021/jo00170a014

Reference yield:

→ (17Ξ)-4,5α-epoxy-17-methyl-17-oxy-morphin-7-ene-3,6α-diol (639-46-3,60827-72-7,60828-57-1)

Guidance literature:

Morphin, Aminophenazol, Metabolismus;

DOI:10.1111/j.2042-7158.1968.tb09635.x

Reference yield:

→ (17Ξ)-4,5α-epoxy-17-methyl-17-oxy-morphin-7-ene-3,6α-diol (639-46-3,60827-72-7,60828-57-1)

Guidance literature:

Morphin,H2O2;

upstream raw materials:

MORPHIN

Refernces

• 1、 Vagujfalvi, Dezsoe,Petz-Stifter, Maria. "ENZYMATIC TRANSFORMATIONS OF MORPHINANE ALKALOIDS". . p. 1533 - 1536. Retrieved 2007/10/02.
• 2、 KELENTEY,STENSZKY,CZOLLNER,SZLAVIK,MESZAROS. "Preparation and pharmacological investigation of N-oxides of opium alkaloids.". . p. 594 - 597. Retrieved 2007/10/04.