Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylthio)phenyl]eth yl]-

Base Information

• Chemical Name: Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylthio)phenyl]eth yl]-
• CAS No.: 14052-59-6
• Molecular Formula: C12H15Cl2NO3S
• Molecular Weight: 324.228
• Mol file: 14052-59-6.mol

Synonyms:

Chemical Property of Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylthio)phenyl]eth yl]-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylthio)phenyl]eth yl]-

There total 7 articles about Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylthio)phenyl]eth yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(+/-)-2-dichloroacetamido-β-hydroxy-4-methylmercaptopropiophenone (119293-92-4) → D-threo-1-p-methylmercaptophenyl-2-dichloroacetamidopropane-1,3-diol (14052-59-6)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1002/jps.2600771215

Reference yield:

(+/-)-2-dichloroacetamido-β-hydroxy-4-methylmercaptopropiophenone (119293-92-4) → (1RS,2RS)-2-(2,2-dichloro-acetylamino)-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol (4302-89-0,6631-50-1,13185-24-5,14052-59-6,27348-37-4,27348-49-8,27348-50-1,71830-03-0)

Guidance literature:

With aluminum isopropoxide; isopropyl alcohol;

DOI:10.1021/ja01141a074

Reference yield:

dichloroacetyl-phosphorous acid diethyl ester (872302-03-9) + (1RS,2RS)-2-amino-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol (14172-52-2,16854-32-3,23150-35-8,27348-36-3,27348-47-6,27348-48-7,36624-58-5) → (1RS,2RS)-2-(2,2-dichloro-acetylamino)-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol (4302-89-0,6631-50-1,13185-24-5,14052-59-6,27348-37-4,27348-49-8,27348-50-1,71830-03-0)

Guidance literature:

With ethanol; sodium acetate;

upstream raw materials:

pentachloroacetone

(1RS,2RS)-2-amino-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol

dichloroacetyl-phosphorous acid diethyl ester

(+/-)-2-dichloroacetamido-β-hydroxy-4-methylmercaptopropiophenone

Downstream raw materials:

(1R,2R)-2-amino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol

(1S,2S)-2-amino-1-(4-(methylsulfonyl)phenyl)propane-1,3-diol

(1S,2S)-(+)-thiomicamine

(R*,R*)-(+)-thiomicamine

Refernces

• 1、 Gal,Meyer-Lehnert. "Reversed-phase liquid chromatographic separation of enantiomeric and diastereomeric bases related to chloramphenicol and thiamphenicol.". . p. 1062 - 1065. Retrieved 2007/10/02.