(+)METHYL ALPHA-(2-THIENYLETHYLAMINO)(2-CHLOROPHENYL)ACETATE HCL

Base Information

• Chemical Name: (+)METHYL ALPHA-(2-THIENYLETHYLAMINO)(2-CHLOROPHENYL)ACETATE HCL
• CAS No.: 141109-18-4
• Molecular Formula: C15H16ClNO2S.ClH
• Molecular Weight: 346.27200
• Mol file: 141109-18-4.mol

Synonyms:Methyl 2-(2-chlorophenyl)-2-((2-(thiophen-2-yl)ethyl)aMino)acetate hydrochloride;METHYL A-[[2-(THIEN-2-YL)ETHYL]AMINO]-A-(2-CHLOROPHENYL)ACETATE HYDROCHLORIDE;

Chemical Property of (+)METHYL ALPHA-(2-THIENYLETHYLAMINO)(2-CHLOROPHENYL)ACETATE HCL

Chemical Property:

• Vapor Pressure: 2.73E-08mmHg at 25°C
• Boiling Point: 444oC at 760 mmHg
• Flash Point: 222.4oC
• PSA: 66.57000
• LogP: 4.64080

Purity/Quality:

99% ^*data from raw suppliers

(+)METHYL ALPHA-(2-THIENYLETHYLAMINO)(2-CHLOROPHENYL)ACETATE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)METHYL ALPHA-(2-THIENYLETHYLAMINO)(2-CHLOROPHENYL)ACETATE HCL

There total 11 articles about (+)METHYL ALPHA-(2-THIENYLETHYLAMINO)(2-CHLOROPHENYL)ACETATE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate (141109-20-8) → (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride (141109-18-4,141109-19-5)

Guidance literature:

With hydrogenchloride; In water;

Reference yield: 96.61%

2-(2-thienyl)ethyl tosylate (40412-06-4) + α-amino-(2-chlorophenyl)acetic acid methyl ester (141109-16-2) → (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride (141109-18-4,141109-19-5)

Guidance literature:

2-(2-thienyl)ethyl tosylate; α-amino-(2-chlorophenyl)acetic acid methyl ester; With sodium hydrogencarbonate; In acetonitrile; at 60 - 70 ℃; for 48h;

With hydrogenchloride; In acetone; at -5 ℃; for 2h; Temperature; Solvent; Reagent/catalyst;

Reference yield: 92.0%

2-(2-thienyl)ethyl tosylate (40412-06-4) + (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt (213018-92-9,212838-70-5) → (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride (141109-18-4,141109-19-5)

Guidance literature:

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt; With sodium carbonate; In water; at 20 ℃; Green chemistry;

2-(2-thienyl)ethyl tosylate; With dipotassium hydrogenphosphate; In water; at 70 - 95 ℃; for 11h; Green chemistry;

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; pH=1.5; Solvent; Temperature; Reagent/catalyst; Green chemistry;

upstream raw materials:

2-(2-thienyl)ethyl tosylate

(S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate

Downstream raw materials:

(S)-(+)-clopidogrel bisulfate

C₁₆H₁₄⁽²⁾H₂ClNO₂S

Refernces

• 1、 -. "Preparation method of clopidogrel hydrogen sulfate intermediate". Paragraph 0032; 0035-0073; 0083. . Retrieved 2021/05/15.
• 2、 -. "Preparation method of sulfonic clopidogrel impurity". Paragraph 0012; 0034-0035. . Retrieved 2020/08/02.