4-broMo-2-phenylthiazole

Base Information

• Chemical Name: 4-broMo-2-phenylthiazole
• CAS No.: 141305-40-0
• Molecular Formula: C9H6BrNS
• Molecular Weight: 240.123
• Hs Code.: 2934100090
• Mol file: 141305-40-0.mol

Synonyms:THIAZOLE,4-BROMO-2-PHENYL;2-phenyl-4-bromothiazole;4-bromo-2-phenylthiazole;

Chemical Property of 4-broMo-2-phenylthiazole

Chemical Property:

• PSA: 41.13000
• LogP: 3.57260

Purity/Quality:

98% ^*data from raw suppliers

4-bromo-2-phenylthiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-broMo-2-phenylthiazole

There total 8 articles about 4-broMo-2-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4-dibromo-1,3-thiazole (4175-77-3) + phenylboronic acid (98-80-6) → 4-bromo-2-phenylthiazole (141305-40-0)

Guidance literature:

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 90 ℃; for 18h; Inert atmosphere;

Reference yield: 97.0%

5-bromo-2-phenyl-1,3-thiazole (53715-67-6) → 4-bromo-2-phenylthiazole (141305-40-0)

Guidance literature:

5-bromo-2-phenyl-1,3-thiazole; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.16667h; Inert atmosphere;

With water; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201201265

Reference yield: 88.0%

2-phenyl-4,5-dibromo-thiazole (105361-77-1) → 4-bromo-2-phenylthiazole (141305-40-0)

Guidance literature:

With sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 25 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.molcata.2014.06.012

upstream raw materials:

2-phenylthiazol-4-one

phenyllithium

2,4-dibromo-1,3-thiazole

5-bromo-2-phenyl-1,3-thiazole

Downstream raw materials:

4-bromo-5-chloro-2-phenylthiazole

2-phenyl-4,5-dibromo-thiazole

2,4-diphenylthiazole

2-phenyl-4-(2-thienyl)-thiazole

Refernces

• 1、 -. "TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE". Page/Page column 77; 78. . Retrieved 2020/05/15.
• 2、 -. "NOVEL COMPOUND, PHOTOACID GENERATOR CONTAINING THE COMPOUND, AND PHOTOSENSITIVE RESIN COMPOSITION CONTAINING THE PHOTOACID GENERATOR". Paragraph 0075; 0076. . Retrieved 2018/12/05.