4-Hydroxynonenal

Base Information Edit

Chemical Name:4-Hydroxynonenal
CAS No.:75899-68-2
Deprecated CAS:128946-65-6,18286-49-2
Molecular Formula:C9H16 O2
Molecular Weight:156.225
Hs Code.:2912491000
UNII:K1CVM13F96
DSSTox Substance ID:DTXSID4040395
Nikkaji Number:J356.016C,J34.593H
Wikipedia:4-Hydroxynonenal
Wikidata:Q229982
Pharos Ligand ID:ATV4TMB7GPHM
Metabolomics Workbench ID:3449
ChEMBL ID:CHEMBL454280
Mol file:75899-68-2.mol

Synonyms:4-HNE cpd;4-hydroxy-2,3-nonenal;4-hydroxy-2-nonenal;4-hydroxy-2-nonenal, (E)-isomer;4-hydroxynonen-2-al;4-hydroxynonenal

Suppliers and Price of 4-Hydroxynonenal

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
HNE
100ug
$ 631.00

Usbiological
4-HNE
48Tests
$ 588.00

Usbiological
4-Hydroxynonenal
48Tests
$ 588.00

Usbiological
HNE
100ul
$ 489.00

Usbiological
HNE
5mg
$ 469.00

TRC
4-Hydroxynonenal
10mg
$ 1630.00

Sigma-Aldrich
4-Hydroxynonenal-CAS75899-68-2-Calbiochem 4-Hydroxynonenal,CAS75899-68-2,isamajoraldehydeproductformedbyperoxida
1 mg
$ 109.15

Cayman Chemical
4-hydroxy Nonenal ≥98%
50mg
$ 1770.00

Cayman Chemical
4-hydroxy Nonenal ≥98%
10mg
$ 413.00

Cayman Chemical
4-hydroxy Nonenal ≥98%
5mg
$ 236.00

Total 42 raw suppliers

Chemical Property of 4-Hydroxynonenal Edit

Chemical Property:

Appearance/Colour:Colorless oil
Boiling Point:275.6 °C at 760 mmHg
PKA:13.31±0.20(Predicted)
Flash Point:115.2 °C
PSA：37.30000
Density:0.941 g/cm³
LogP:1.68270
Storage Temp.:-70°C
Water Solubility.:Solubile in DMSO, Ethanol, Hexane
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:156.115029749
Heavy Atom Count:11
Complexity:119

Purity/Quality:

99% ^*data from raw suppliers

HNE ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC=O)O
Isomeric SMILES:CCCCCC(/C=C/C=O)O
Uses HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 μM.[Cayman Chemical] 4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity.

Technology Process of 4-Hydroxynonenal

There total 45 articles about 4-Hydroxynonenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 109296-10-8
4-hydroxy-trans-2-nonenal-dimethylacetal

: 75899-68-2,18286-49-2,29343-52-0
(E)-4-Hydroxy-2-nonenal

Guidance literature:: With sulfuric acid; In tetrahydrofuran; water; for 1h; Ambient temperature;

Reference yield: 97.0%

: C₂₇H₂₉O₆^(1-)*K⁽¹⁺⁾

: 1086461-21-3
1-hydroxy-2-propyl-9,10-anthraquinone-4-carboxylic acid

: 75899-68-2,18286-49-2,29343-52-0
(E)-4-Hydroxy-2-nonenal

Guidance literature:: C₂₇H₂₉O₆^(1-)*K⁽¹⁺⁾; In water; for 2.5h; pH=9; aq. buffer; Irradiation;

With hydrogenchloride; In water;
DOI:10.1039/b810954k

Reference yield: 94.0%

: (±)-anti-4-(2-hydroxyethyl)-5-pentyl-1,3-dioxolan-2-one

: 75899-68-2,18286-49-2,29343-52-0
(E)-4-Hydroxy-2-nonenal

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 3h; Reagent/catalyst; Solvent; stereoselective reaction; Inert atmosphere; Reflux;
DOI:10.1002/asia.201900421