(2-Aminoethyl)phosphonic acid

Base Information

• Chemical Name: (2-Aminoethyl)phosphonic acid
• CAS No.: 2041-14-7
• Molecular Formula: C2H8NO3P
• Molecular Weight: 125.064
• Hs Code.: 29319000
• Mol file: 2041-14-7.mol

Synonyms:Phosphonicacid, (2-aminoethyl)- (6CI,7CI,8CI,9CI);2-Aminoethanephosphonic acid;Ciliatine;NSC 133837;Phosphonoethylamine;b-Aminoethylphosphonic acid;

Chemical Property of (2-Aminoethyl)phosphonic acid

Chemical Property:

• Appearance/Colour: white to beige crystalline powder
• Vapor Pressure: 6.5E-06mmHg at 25°C
• Melting Point: 296 °C (dec.)(lit.)
• Boiling Point: 352.5 °C at 760 mmHg
• PKA: pK1: 2.45(+1) ;pK2: 7.0(0);pK3: 10.8(-1) (25°C)
• Flash Point: 167 °C
• PSA: 93.36000
• Density: 1.482 g/cm³
• LogP: -0.17690
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: water: soluble50mg/mL, clear, colorless
• Water Solubility.: Soluble
• XLogP3: -4.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 125.02418011
• Heavy Atom Count: 7
• Complexity: 84.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Aminoethylphosphonic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 26-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CP(=O)(O)[O-])[NH3+]
• Uses: 2-Aminoethylphosphonic acid was used as a growth medium for the marine bacterium Roseovarius nubinhibens ISM.

Technology Process of (2-Aminoethyl)phosphonic acid

There total 24 articles about (2-Aminoethyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-benzyloxycarbonylamino-ethyl)-phosphonic acid diethyl ester (70908-62-2) → (2-aminethyl)phosphonic acid (2041-14-7)

Guidance literature:

With hydrogenchloride; for 20h; Heating;

DOI:10.1016/S0040-4020(01)86836-8

Reference yield: 88.0%

2-chloroethylphosphonic acid (16672-87-0) + ammonia (7664-41-7) → (2-aminethyl)phosphonic acid (2041-14-7)

Guidance literature:

With sodium hydroxide; potassium iodide; at 20 ℃; for 172h; pH=8; Acid hydrolysis;

DOI:10.1080/00397919808004835

Reference yield: 81.0%

bis(trimethylsilyl) <2-<(methoxycarbonyl)(trimethylsilyl)amino>ethyl> phosphonate → (2-aminethyl)phosphonic acid (2041-14-7)

Guidance literature:

With hydrogen bromide; for 10h; Heating;

upstream raw materials:

2-(2-bromoethyl)isoindoline-1,3-dione

triethyl phosphite

(2-amino-ethyl)-phosphonic acid dibutyl ester

diethyl 1-cyanomethylphosphonate

Downstream raw materials:

(R)-(-)-(2-Amino-1-hydroxyethyl)phosphonsaeure

(2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid

phosphoric acid

[2-(6-amino-9-benzyl-9H-purin-8-ylamino)-ethyl]-phosphonic acid

Refernces

• 1、 Fontana, Jose D.,Duarte, Jose H.,Gallo, Ciro B. H.,Iacomini, Marcello,Gorin, Philip A. J.. "OCCURRENCE OF β-D-GALACTOPYRANOSYL UNITS ESTERIFIED AT O-6 WITH 2-AMINOETHYLPHOSPHONIC ACID IN THE D-GALACTAN OF ALBUMEN GLANDS OF THE SNAIL MEGALOBULIMUS PARANAGUENSIS". . p. 175 - 184. Retrieved 1985.
• 2、 Cameron, David G.,Hudson, Harry R.,Pianka, Max. "ORGANOPHOSPHORUS COMPOUNDS AS POTENTIAL FUNGICIDES. PART II. AMINOALKANE-, GUANIDINOALKANE-, AND THIOUREIDOALKANE-PHOSPHONIC ACIDS: PREPARATION, SPECTROSCOPY, AND FUNGICIDAL ACTIVITY". . p. 21 - 38. Retrieved 2007/10/02.
• 3、 Hammerschmidt, Friedrich,Kaehlig, Hanspeter,Mueller, Norbert. "Biosynthesis of Naturally Products with a P-C Bond. Part 6. Preparation of Deuterium- and Carbon-13-Labelled L-Alanyl- and L-Alanyl-L-alanyl-(2-aminoethyl)phosphonic Acids and their Use in Biosynthetic Studies of Fosfomycin in Streptomyces fradiae". . p. 365 - 369. Retrieved 2007/10/02.