RARECHEM AL BO 1277

Base Information

• Chemical Name: RARECHEM AL BO 1277
• CAS No.: 14758-99-7
• Molecular Formula: C10H13 N O2
• Molecular Weight: 179.219
• Mol file: 14758-99-7.mol

Synonyms:Glycine,N,N-dimethyl-2-phenyl- (6CI,8CI); NSC 241086

Chemical Property of RARECHEM AL BO 1277

Chemical Property:

• Vapor Pressure: 0.0053mmHg at 25°C
• Boiling Point: 263.1°Cat760mmHg
• Flash Point: 112.9°C
• PSA: 40.54000
• Density: 1.135g/cm³
• LogP: 1.37390
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

α-(Dimethylamino)phenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Amino acid derivative.

Technology Process of RARECHEM AL BO 1277

There total 6 articles about RARECHEM AL BO 1277 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methylamino-2-phenylacetic acid (74641-60-4) → N,N-dimethyl-α-phenylglycine (14758-99-7)

Guidance literature:

With formic acid; for 4h; Heating;

DOI:10.1246/bcsj.66.1430

Reference yield: 89.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenylglycin (2835-06-5) → N,N-dimethyl-α-phenylglycine (14758-99-7)

Guidance literature:

With sodium tetrahydroborate; In 2,2,2-trifluoroethanol; for 40h; Reflux;

DOI:10.1055/s-0030-1258384

Reference yield:

2-bromophenylacetic acid (4870-65-9,31302-84-8) → N,N-dimethyl-α-phenylglycine (14758-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72.1 percent / methanol / 3 h / 20 °C

2: 90.2 percent / aq. formic acid / 4 h / Heating

With formic acid; In methanol;

DOI:10.1246/bcsj.66.1430

upstream raw materials:

formaldehyd

phenylglycin

2-methylamino-2-phenylacetic acid

carbon dioxide

Downstream raw materials:

bis(D,L-N,N-dimethyl-C-phenylglycinato-N,O)palladium(II)

N-{2-[4-(3-Cyclohexyl-2-imino-imidazolidine-1-sulfonyl)-phenyl]-ethyl}-2-dimethylamino-2-phenyl-acetamide

N,N-dimethyl acetamide

Refernces

• 1、 Ebden, Mark R.,Simpkins, Nigel S.,Fox, David N.A.. "Metallation of benzylic amines via amine-borane complexes". . p. 12923 - 12952. Retrieved 2007/10/03.