Tyrosine, 2-fluoro-5-methoxy-

Base Information

• Chemical Name: Tyrosine, 2-fluoro-5-methoxy-
• CAS No.: 141554-67-8
• Molecular Formula: C10H12FNO4
• Molecular Weight: 229.208
• Mol file: 141554-67-8.mol

Synonyms:

Chemical Property of Tyrosine, 2-fluoro-5-methoxy-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tyrosine, 2-fluoro-5-methoxy-

There total 17 articles about Tyrosine, 2-fluoro-5-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-3-(4-benzyloxy-2-fluoro-5-methoxy-phenyl)-propionic acid → 3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine (141554-67-8,114077-01-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 6h; under 1034.3 Torr; Yield given; Ambient temperature;

Reference yield:

benzyl bromide (100-39-0) → 3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine (141554-67-8,114077-01-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 42 percent / K₂CO₃ / acetone / 24 h / Ambient temperature

2: 89 percent / K₂CO₃ / acetone / 16 h / Heating

3: 78.8 percent / NaOAc, HOAc / 2 h / 95 °C

4: 40percent NaOH / ethanol; H₂O / 0.17 h / Heating

5: 62.8 percent / H₂ / 10percent Pd-C / methanol / 6 h / 2068.6 - 2327.2 Torr

6: 3N HCl / 24 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; sodium acetate; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; ethanol; water; acetone;

DOI:10.1016/S0022-1139(00)82354-4

Reference yield:

4-Benzyloxy-2-fluoro-5-methoxybenzaldehyde (79418-72-7) → 3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine (141554-67-8,114077-01-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 78.8 percent / NaOAc, HOAc / 2 h / 95 °C

2: 40percent NaOH / ethanol; H₂O / 0.17 h / Heating

3: 62.8 percent / H₂ / 10percent Pd-C / methanol / 6 h / 2068.6 - 2327.2 Torr

4: 3N HCl / 24 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; In methanol; ethanol; water;

DOI:10.1016/S0022-1139(00)82354-4

upstream raw materials:

N-Benzoyl-3-(2-fluoro-4-hydroxy-5-methoxyphenyl)alanine

N-trifluoroacetyl-3-methoxy-4-trimethylacetoxy-6-fluorophenylalanine ethyl ester

2-bromo-4-fluoro-1-methoxybenzene

5-fluoro-2-methoxy phenol

Refernces

• 1、 Luxen, A.,Monclus, M.,Hendrickx, P.-Y.,Masson, C.,Melega, W. P.. "SYNTHESIS AND HPLC SEPARATION OF 6-FLUORO-L-DOPA METABOLITES". . p. 217 - 226. Retrieved 2007/10/02.