3-(2-Fluorophenyl)cyclohexanone

Base Information

• Chemical Name: 3-(2-Fluorophenyl)cyclohexanone
• CAS No.: 141632-21-5
• Molecular Formula: C12H13FO
• Molecular Weight: 192.22900
• Mol file: 141632-21-5.mol

Synonyms:3-(2-fluorophenyl)cyclohexan-1-one;

Chemical Property of 3-(2-Fluorophenyl)cyclohexanone

Chemical Property:

• PSA: 17.07000
• LogP: 3.05240

Purity/Quality:

98% ^*data from raw suppliers

3-(2-Fluorophenyl)cyclohexanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Fluorophenyl)cyclohexanone

There total 9 articles about 3-(2-Fluorophenyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexenone (930-68-7) + o-fluorophenylboronic acid (1993-03-9) → (S)-3-(2-fluorophenyl)cyclohexan-1-one (141632-21-5)

Guidance literature:

With potassium hydroxide; R,R,R-5-All-3-iBu-8-MeO-1,8-Me₂bicyclo[2.2.2]octa-2,5-diene; Rh(H₂C=CH₂)2Cl; In 1,4-dioxane; water; at 50 ℃;

DOI:10.1021/ol048240x

Reference yield: 72.0%

cyclohexenone (930-68-7) + o-fluorophenylboronic acid (1993-03-9) → 3-(2-fluorophenyl)cyclohexanone (141632-21-5)

Guidance literature:

With potassium hydroxide; [{(P,R,R)-p-tol-BINASO}RhCl]2; In toluene; at 40 ℃; for 1h;

DOI:10.1021/ja710665q

Reference yield: 72.0%

cyclohexenone (930-68-7) + o-fluorophenylboronic acid (1993-03-9) → 3-(2-fluorophenyl)cyclohexan-1-one (141632-21-5)

Guidance literature:

With Rh(acac)(COD); In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;

DOI:10.1039/c9cc00923j

upstream raw materials:

cyclohexenone

o-fluorophenylboronic acid

Refernces

• 1、 Gilbert, Sophie H.,Viseur, Virginie,Clarke, Matthew L.. "A consecutive process for C-C and C-N bond formation with high enantio-and diastereo-control: Direct reductive amination of chiral ketones using hydrogenation catalysts". supporting information. p. 6409 - 6412. Retrieved 2019/06/07.
• 2、 Zhao, Guang-Zhen,Foster, Daven,Sipos, Gellért,Gao, Pengchao,Skelton, Brian W.,Sobolev, Alexandre N.,Dorta, Reto. "Electronic and Steric Tuning of an Atropisomeric Disulfoxide Ligand Motif and Its Use in the Rh(I)-Catalyzed Addition Reactions of Boronic Acids to a Wide Range of Acceptors". . p. 9741 - 9755. Retrieved 2018/09/06.