2H-1,4-Benzoxazine-3(4H)-thione

Base Information

• Chemical Name: 2H-1,4-Benzoxazine-3(4H)-thione
• CAS No.: 14183-51-8
• Molecular Formula: C8H7NOS
• Molecular Weight: 165.216
• Hs Code.: 2934999090
• Mol file: 14183-51-8.mol

Synonyms:2,3-Dihydro-3-thio-1,4-benzoxazine;3,4-dihydro-2H-1,4-benzoxazin-3-one;2H-1,4-Benzoxazin-3-one;benzoxazin-3-one;

Chemical Property of 2H-1,4-Benzoxazine-3(4H)-thione

Chemical Property:

• PSA: 60.39000
• LogP: 1.47440

Purity/Quality:

99% ^*data from raw suppliers

2H-1,4-benzoxazine-3(4H)-thione ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-1,4-Benzoxazine-3(4H)-thione

There total 7 articles about 2H-1,4-Benzoxazine-3(4H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,4-dihydro-3-oxo-2H-1,4-benzoxazine (5466-88-6) → 2H-1,4-benzoxazin-3(4H)-thione (14183-51-8)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1007/BF00810287

Reference yield:

2H-1,4-benzoxazin-3(4H)-thione (14183-51-8) → 2H-benzo[b][1,4]oxazine-3-thiol (14183-51-8)

Guidance literature:

With diethylamine; In acetone; Reflux;

Reference yield:

2-methoxy-phenylamine (90-04-0) → 2H-benzo[b][1,4]oxazine-3-thiol (14183-51-8)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; sodium carbonate / toluene / 4 h / 50 °C / 1500.15 Torr / Autoclave

2: Lawessons reagent / 10 h / Reflux

3: diethylamine / acetone / Reflux

With Lawessons reagent; palladium diacetate; sodium carbonate; diethylamine; In acetone; toluene;

upstream raw materials:

3,4-dihydro-3-oxo-2H-1,4-benzoxazine

2-amino-phenol

2-methoxy-phenylamine

Downstream raw materials:

3,4-dihydro-3-oxo-2H-1,4-benzoxazine

6,7-dibromo-(2H)-1,4-benzoxazin-3(4H)-one

(2H-benzo[1,4]oxazin-3-yl)-phenyl-amine

2-(2H-1,4-Benzoxazin-3-ylthio)-1-phenyl-1-ethanon

Refernces

• 1、 -. "1. 4 - benzoxazine - 1, 2, 3 - triazole class compound and its synthetic method and application". Paragraph 0029-0032. . Retrieved 2017/08/25.
• 2、 -. "Preparation method of benzoxazine-and-pyrazol-calcium complex with anti-platelet aggregation activity". Paragraph 0022; 0027; 0028. . Retrieved 2017/12/27.