4-Chlorophenyl glycidyl ether

Base Information

• Chemical Name: 4-Chlorophenyl glycidyl ether
• CAS No.: 2212-05-7
• Molecular Formula: C9H9 Cl O2
• Molecular Weight: 184.622
• Hs Code.: 2910900090
• European Community (EC) Number: 218-655-8
• NSC Number: 60260
• Nikkaji Number: J166J
• Mol file: 2212-05-7.mol

Synonyms:4-Chlorophenyl glycidyl ether;2212-05-7;2-[(4-chlorophenoxy)methyl]oxirane;p-Chlorophenyl glycidyl ether;Chlorophenyl glycidyl ether;2-((4-Chlorophenoxy)methyl)oxirane;4-Chlorophenyl 2,3-epoxypropyl ether;2-(4-chlorophenoxymethyl)oxirane;1,2-Epoxy-3-chlorophenoxypropane;2-(4-CHLORO-PHENOXYMETHYL)-OXIRANE;NSC 60260;1,2-Epoxy-3-(p-chlorophenoxy)propane;Propane, 1-(p-chlorophenoxy)-2,3-epoxy-;((4-Chlorophenoxy)methyl)oxirane;EINECS 218-655-8;p-Chlorophenyl 2,3-epoxypropyl ether;2,3-Epoxypropyl-4-chlorophenyl ether;Oxirane, ((4-chlorophenoxy)methyl)-;Oxirane, [(4-chlorophenoxy)methyl]-;BRN 0122151;AI3-13111;4-chlorophenylglycidyl ether;Glycidyl p-chlorophenyl ether;(4-chlorophenoxymethyl)oxirane;SCHEMBL1582722;KSLSZOOZWRMSAP-UHFFFAOYSA-;4-chlorophenoxy-2,3-epoxypropane;NSC60260;4-Chlorophenyl glycidyl ether, 99%;MFCD00005134;NSC-60260;AKOS000122883;AKOS016051070;1-(p-Chlorophenoxy)-2,3-epoxypropane;AB00382;SB46171;4-chloro-1-(2,3-epoxypropoxy)benzene;AS-60019;LS-119676;CS-0238018;FT-0634131;EN300-18909;V10254;Z94602271

Chemical Property of 4-Chlorophenyl glycidyl ether

Chemical Property:

• Vapor Pressure: 0.00952mmHg at 25°C
• Melting Point: 31-33 °C(lit.)
• Refractive Index: n20/D 1.545(lit.)
• Boiling Point: 273.5°Cat760mmHg
• Flash Point: 107.2°C
• PSA: 21.76000
• Density: 1.267g/cm³
• LogP: 2.11760
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chlorophenyl glycidyl ether 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(O1)COC2=CC=C(C=C2)Cl

Technology Process of 4-Chlorophenyl glycidyl ether

There total 11 articles about 4-Chlorophenyl glycidyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-allyloxy-4-chlorobenzene (13997-70-1) → 4-chlorophenyl 2,3-epoxypropyl ether (2212-05-7)

Guidance literature:

With dihydrogen peroxide; In methanol; water; acetonitrile; at 40 ℃; for 67h; chemoselective reaction;

DOI:10.1002/ejoc.202000249

Reference yield: 90.0%

4-chloro-phenol (106-48-9,82344-39-6) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 4-chlorophenyl 2,3-epoxypropyl ether (2212-05-7)

Guidance literature:

With n-Bu₄NOSO₂OCH₂CHOHCH₃; potassium carbonate; at 75 - 80 ℃; for 1h;

DOI:10.1080/00397919408011305

Reference yield: 90.0%

Phenyl glycidyl ether (122-60-1,71031-02-2) → 4-chlorophenyl 2,3-epoxypropyl ether (2212-05-7)

Guidance literature:

With tetraethylammonium chloride; trichloroacetonitrile; In acetonitrile; at 23 ℃; for 2h; Electrochemical reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00704

upstream raw materials:

4-chloro-phenol

epichlorohydrin

2-((2-bromo-4-chlorophenoxy)methyl)oxirane

2-bromo-4-chlorophenol

Downstream raw materials:

3-[3-(4-Chloro-phenoxy)-2-hydroxy-propylamino]-benzoic acid ethyl ester

4-[3-(4-Chloro-phenoxy)-2-hydroxy-propoxy]-benzoic acid ethyl ester

4-[3-(4-Chloro-phenoxy)-2-oxo-propoxy]-benzoic acid propyl ester

4-[3-(4-Chloro-phenoxy)-2-hydroxy-propoxy]-benzoic acid propyl ester

Refernces

• 1、 Babbar, Palak,Das, Pronay,Manickam, Yogavel,Mankad, Yash,Yadav, Swati,Parvez, Suhel,Sharma, Amit,Reddy, D. Srinivasa. "Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites". . p. 1777 - 1794. Retrieved 2021/05/10.
• 2、 -. "Substituted diaryl compound and preparation method and application thereof". Paragraph 0073-0075; 0076. . Retrieved 2021/09/15.