Benzyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate

Base Information Edit

Chemical Name:Benzyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate
CAS No.:143264-54-4
Molecular Formula:C15H19NO3
Molecular Weight:261.321
Hs Code.:2933399090
DSSTox Substance ID:DTXSID10448151
Nikkaji Number:J3.410.961C
Wikidata:Q82267108
Mol file:143264-54-4.mol

Synonyms:143264-54-4;Benzyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate;DTXSID10448151;1-(Benzyloxycarbonyl)piperidine-2alpha-acetaldehyde

Suppliers and Price of Benzyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Benzyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate Edit

Chemical Property:

PSA：46.61000
LogP:2.70460
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:261.13649347
Heavy Atom Count:19
Complexity:300

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C(C1)CC=O)C(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CCN([C@@H](C1)CC=O)C(=O)OCC2=CC=CC=C2

Technology Process of Benzyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate

There total 20 articles about Benzyl (2S)-2-(2-oxoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 173425-07-5
<2S,2(2R),2(3S)>-N-<(benzyloxy)carbonyl>-2-(2,3-dihydroxy-4-methylpentyl)piperidine

: 143264-54-4
(2S)-N-<(benzyloxy)carbonyl>-2-(formylmethyl)piperidine

Guidance literature:: With periodic acid; In tetrahydrofuran; water; at 0 ℃; for 2h;
DOI:10.1021/jo9518258

Reference yield:

: 34418-91-2
2,3,4,5-tetrahydropyridine N-oxide

: 143264-54-4
(2S)-N-<(benzyloxy)carbonyl>-2-(formylmethyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / toluene / 14 h / Heating

2: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 45 °C

3: 91 percent / H₂, PdCl₂ / methanol / 37 h / 4940 Torr

4: 85 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 14 h / Ambient temperature

5: 84 percent / HIO₄ / tetrahydrofuran; H₂O / 2 h / 0 °C

With tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; periodic acid; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jo9518258

Reference yield:

: 173425-05-3
<2R,2(1S),3aS>-2-(1-hydroxy-2-methylpropyl)-3,3a,4,5,6,7-hexahydro-2H-isoxazolo<2,3-a>pyridine

: 143264-54-4
(2S)-N-<(benzyloxy)carbonyl>-2-(formylmethyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / H₂, PdCl₂ / methanol / 37 h / 4940 Torr

2: 85 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 14 h / Ambient temperature

3: 84 percent / HIO₄ / tetrahydrofuran; H₂O / 2 h / 0 °C

With hydrogen; sodium carbonate; periodic acid; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo9518258