Cyclopentanecarbonyl chloride, 1-(4-bromophenyl)-

Base Information

• Chemical Name: Cyclopentanecarbonyl chloride, 1-(4-bromophenyl)-
• CAS No.: 143328-29-4
• Molecular Formula: C12H12BrClO
• Molecular Weight: 287.584
• Mol file: 143328-29-4.mol

Synonyms:

Chemical Property of Cyclopentanecarbonyl chloride, 1-(4-bromophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarbonyl chloride, 1-(4-bromophenyl)-

There total 5 articles about Cyclopentanecarbonyl chloride, 1-(4-bromophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

1-(4-bromophenyl)cyclopentanecarboxylic acid (143328-24-9) → 1-(4-bromophenyl)cyclopentane-1-carboxylic acid chloride (143328-29-4)

Guidance literature:

With thionyl chloride; In benzene; for 8h; Heating;

DOI:10.1007/BF00766460

Reference yield:

4-Bromophenylacetonitrile (16532-79-9) → 1-(4-bromophenyl)cyclopentane-1-carboxylic acid chloride (143328-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaOH / 1.) 45 deg C, 2.) 120 deg C, 12 h

2: 60.4 percent / KOH / various solvent(s) / 12 h / Heating

3: 47.6 percent / SOCl₂ / benzene / 8 h / Heating

With potassium hydroxide; sodium hydroxide; thionyl chloride; In benzene;

DOI:10.1007/BF00766460

Reference yield:

1-(4-bromophenyl)cyclopentane-1-carbonitrile (143328-19-2) → 1-(4-bromophenyl)cyclopentane-1-carboxylic acid chloride (143328-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 60.4 percent / KOH / various solvent(s) / 12 h / Heating

2: 47.6 percent / SOCl₂ / benzene / 8 h / Heating

With potassium hydroxide; thionyl chloride; In benzene;

DOI:10.1007/BF00766460

upstream raw materials:

1-(4-bromophenyl)cyclopentanecarboxylic acid

4-Bromophenylacetonitrile

1-(4-bromophenyl)cyclopentane-1-carbonitrile

(4-bromo-phenyl)-acetic acid methyl ester

Downstream raw materials:

Sodium; (6R,7R)-7-{[1-(4-bromo-phenyl)-cyclopentanecarbonyl]-amino}-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Sodium; (2S,5R,6R)-6-{[1-(4-bromo-phenyl)-cyclopentanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Sodium; (6R,7R)-3-acetoxymethyl-7-{[1-(4-bromo-phenyl)-cyclopentanecarbonyl]-amino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Refernces

• 1、 -. "Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof". Paragraph 0313; 0314; 0319; 0320. . Retrieved 2021/07/09.
• 2、 Mndzhoyan, Sh. L.,Kramer, M. S.,Akopyan, S. G.,Grigoryan, M. M.,Ter-Zakharyan, Yu. Z.,et al.. "SYNTHESIS AND ANTIBACTERIAL PROPERTIES OF HALOGEN-CONTAINING 1-PHENYLCYCLOPENTYL-1-PENICILLINS AND -1-CEPHALOSPORINS". . p. 169 - 173. Retrieved 2007/10/02.