3,5-Dimethoxybenzyl alcohol

Base Information

• Chemical Name: 3,5-Dimethoxybenzyl alcohol
• CAS No.: 705-76-0
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Hs Code.: 29094990
• European Community (EC) Number: 211-888-6
• DSSTox Substance ID: DTXSID80220769
• Nikkaji Number: J149.883E
• Wikidata: Q72467710
• Mol file: 705-76-0.mol

Synonyms:3,5-Dimethoxybenzyl alcohol;705-76-0;(3,5-Dimethoxyphenyl)methanol;3,5-Dimethoxybenzylalcohol;Benzenemethanol, 3,5-dimethoxy-;MFCD00004641;EINECS 211-888-6;3,5-Dimethoxy Benzyl Alcohol;3,5-Dimethoxybenzyl alcohole;3,5-dimethoxy-benzylalcohol;3,5-Dimethoxy benzylalcohol;3,5-Dimethoxybenzenemethanol;SCHEMBL65276;3, 5-Dimethoxy benzylalcohol;AUDBREYGQOXIFT-UHFFFAOYSA-;(3,5-dimethoxy-phenyl)-methanol;DTXSID80220769;(3,5-Dimethoxyphenyl)methanol #;AMY41938;BCP18629;3,5-Dimethoxybenzyl alcohol, 99%;AKOS000249222;CS-W017809;FS-3181;AC-24243;SY015072;D2594;FT-0614643;FT-0654900;EN300-132498;AE-641/30608011;W-104549;Z335245222

Chemical Property of 3,5-Dimethoxybenzyl alcohol

Chemical Property:

• Appearance/Colour: White to yellow-beige crystalline solid
• Vapor Pressure: 0.000543mmHg at 25°C
• Melting Point: 46-50 °C
• Refractive Index: 1.521
• Boiling Point: 299.1 °C at 760 mmHg
• PKA: 14.24±0.10(Predicted)
• Flash Point: 134.7 °C
• PSA: 38.69000
• Density: 1.111 g/cm³
• LogP: 1.19610
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 115

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dimethoxybenzyl alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36/37-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)CO)OC
• Uses: 3,5-Dimethoxybenzyl Alcohol is used in the synthesis of Resveratrol (R150000). 3,5-Dimethoxybenzyl alcohol was used as starting material for the synthesis of dendrimeric compounds.

Technology Process of 3,5-Dimethoxybenzyl alcohol

There total 36 articles about 3,5-Dimethoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl((3,5-dimethoxybenzyl)oxy)dimethylsilane → 3,5-dimethoxybenzyl alcohol (705-76-0)

Guidance literature:

With zinc trifluoromethanesulfonate; In methanol; at 0 - 20 ℃; for 0.666667h; chemoselective reaction;

DOI:10.2174/1570178614666170710120051

Reference yield: 91.0%

3,5-dimethoxy((triethylsilyloxy)methyl)benzene (1523213-10-6) → 3,5-dimethoxybenzyl alcohol (705-76-0)

Guidance literature:

With zinc trifluoromethanesulfonate; In methanol; at 0 - 20 ℃; for 0.25h; chemoselective reaction;

DOI:10.2174/1570178614666170710120051

Reference yield: 89.0%

C18H32O3Si → 3,5-dimethoxybenzyl alcohol (705-76-0)

Guidance literature:

With zinc trifluoromethanesulfonate; In methanol; at 0 - 20 ℃; for 1h; chemoselective reaction;

DOI:10.2174/1570178614666170710120051

upstream raw materials:

3,5-dimethoxybenzaldehdye

3,5-dimethoxybenzamide

3,5-dimethoxybenzoic acid

methanol

Downstream raw materials:

1-methylmethoxy-3,5-dimethoxybenzene

1-((benzyloxy)methyl)-3,5-dimethoxybenzene

3,5-dimethoxybenzyl benzoate

9,10-bis-(3,5-dimethoxy-benzyloxymethyl)-anthracene

Refernces

• 1、 Sunnapu, Ranganayakulu,Banoth, Saikumar Naik,Reyno,Thomas, Aleena,Venugopal, Navyasree,Rajendar, Goreti. "Stereoselective Total Synthesis of (-)-(2 S,4 R)-3′-Methoxyl Citreochlorol: Preparation and Use of New Proline-Based Auxiliary for Asymmetric Acetate Aldol Reaction". . p. 4103 - 4113. Retrieved 2020/03/05.
• 2、 Oliveira Filho, Ronaldo E.,Higa, Vanessa M.,Omori, álvaro T.. "Studies toward the synthesis of caramboxin analogues". . p. 528 - 540. Retrieved 2019/08/26.