Phosphinic acid, phenyl-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Phosphinic acid, phenyl-, 1,1-dimethylethyl ester
• CAS No.: 143490-03-3
• Molecular Formula: C10H15O2P
• Molecular Weight: 198.202
• Mol file: 143490-03-3.mol

Synonyms:

Chemical Property of Phosphinic acid, phenyl-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphinic acid, phenyl-, 1,1-dimethylethyl ester

There total 3 articles about Phosphinic acid, phenyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

phenylphosphinic acid (1779-48-2) + tert-butyl alcohol (75-65-0) → O-isopropyl phenylphosphinate (143490-03-3)

Guidance literature:

phenylphosphinic acid; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; for 0.166667h;

tert-butyl alcohol; In ethyl acetate; at 25 ℃; for 1h;

DOI:10.1016/j.tet.2014.09.021

Reference yield:

Dichlorophenylphosphine (644-97-3) + tert-butyl alcohol (75-65-0) → O-isopropyl phenylphosphinate (143490-03-3)

Guidance literature:

With triethylamine; In diethyl ether; at 0 - 20 ℃; for 8h;

DOI:10.1039/c4ob01574f

Reference yield:

t-butyl bromide (507-19-7) + phenylphosphinic acid (1779-48-2) → O-isopropyl phenylphosphinate (143490-03-3)

Guidance literature:

With triethylamine; at 80 ℃; for 3h;

DOI:10.1002/adsc.202100949

upstream raw materials:

Dichlorophenylphosphine

tert-butyl alcohol

phenylphosphinic acid

t-butyl bromide

Downstream raw materials:

(±)-n-butyl(phenyl)phosphine oxide

methyl(phenyl)phosphineoxide

tert-Butylphenylphosphine oxide

Diphenylphosphine oxide

Refernces

• 1、 Sun, Yong-Ming,Xin, Nana,Xu, Zhong-Yuan,Liu, Li-Juan,Meng, Fan-Jie,Zhang, He,Fu, Bao-Ci,Liang, Qiu-Ju,Zheng, Hong-Xing,Sun, Li-Jun,Zhao, Chang-Qiu,Han, Li-Biao. "Addition of optically pure H-phosphinate to ketones: Selectivity, stereochemistry and mechanism". supporting information. p. 9457 - 9465. Retrieved 2014/12/11.