2,4-DIAMINO-6-FLUOROPYRIMIDINE

Base Information

• Chemical Name: 2,4-DIAMINO-6-FLUOROPYRIMIDINE
• CAS No.: 696-83-3
• Molecular Formula: C4H5 F N4
• Molecular Weight: 128.109
• Hs Code.: 2933599090
• Mol file: 696-83-3.mol

Synonyms:Pyrimidine,2,4-diamino-6-fluoro- (7CI,8CI); NSC 527000

Chemical Property of 2,4-DIAMINO-6-FLUOROPYRIMIDINE

Chemical Property:

• Vapor Pressure: 7.2E-07mmHg at 25°C
• Boiling Point: 408.1 °C at 760 mmHg
• PKA: 3.13±0.10(Predicted)
• Flash Point: 200.6 °C
• PSA: 77.82000
• Density: 1.513 g/cm³
• LogP: 0.94250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

6-Fluoropyrimidine-2,4-diamine 98% ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIAMINO-6-FLUOROPYRIMIDINE

There total 2 articles about 2,4-DIAMINO-6-FLUOROPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2,4,6-trifluoropyrimidine (696-82-2) → 4-amino-2,6-difluoropyrimidine (675-12-7) + 2-amino-4,6-difluoropyrimidine (675-11-6) + 2,4-diamino-6-fluoropyrimidine (696-83-3)

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1002/jhet.5570410623

Reference yield:

2,4,6-trifluoropyrimidine (696-82-2) → 2,4-diamino-6-fluoropyrimidine (696-83-3)

Guidance literature:

With ammonium hydroxide; In acetonitrile; at 0 - 40 ℃;

Reference yield:

2,4-diamino-6-fluoropyrimidine (696-83-3) → 2,6-diaminopyrimidin-4-ol (56-06-4)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; Rate constant;

upstream raw materials:

2,4,6-trifluoropyrimidine

Downstream raw materials:

2,6-diaminopyrimidin-4-ol

Refernces

• 1、 Delia, Thomas J.,Anderson, Dennis P.,Schomaker, Jennifer M.. "2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles". . p. 991 - 993. Retrieved 2007/10/03.