2-(4-methyl-1,3-thiazol-2-yl)pyridine

Base Information

• Chemical Name: 2-(4-methyl-1,3-thiazol-2-yl)pyridine
• CAS No.: 14384-69-1
• Molecular Formula: C9H8N2S
• Molecular Weight: 0.00000
• Mol file: 14384-69-1.mol

Synonyms:

Chemical Property of 2-(4-methyl-1,3-thiazol-2-yl)pyridine

Chemical Property:

• Melting Point: 84 °C
• Boiling Point: 324.6±34.0 °C(Predicted)
• PKA: 2.01±0.10(Predicted)
• PSA: 0.00000
• Density: 1.199±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methyl-1,3-thiazol-2-yl)pyridine

There total 4 articles about 2-(4-methyl-1,3-thiazol-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C9H10N2S (1218937-30-4) → 2-(2'-pyridyl)-4-methylthiazole (14384-69-1)

Guidance literature:

With manganese(IV) oxide; In 1,2-dichloro-ethane; for 12h; Inert atmosphere; Reflux;

DOI:10.3390/molecules14124858

Reference yield:

pyridine-2-carbothioamide (5346-38-3) + 1-bromoacetone (598-31-2) → 2-(2'-pyridyl)-4-methylthiazole (14384-69-1)

Guidance literature:

In ethanol; for 10h; Reflux; Inert atmosphere;

DOI:10.1007/s10895-015-1675-1

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → 2-(2'-pyridyl)-4-methylthiazole (14384-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanolic NH₃; H₂S

With hydrogen sulfide; ammonia;

DOI:10.1002/hlca.194502801119

upstream raw materials:

pyridine-2-carbothioamide

chloroacetone

2-Cyanopyridine

C₉H₁₀N₂S

Downstream raw materials:

2-(4-methyl-thiazol-2-yl)-1-(2-oxo-2-phenyl-ethyl)-pyridinium; bromide

Refernces

• 1、 Yu, Yan-Bo,Chen, Hong-Liang,Wang, Li-Yi,Chen, Xin-Zheng,Fu, Bin. "A facile synthesis of 2,4-disubstituted thiazoles using MnO2". experimental part. p. 4858 - 4865. Retrieved 2010/04/05.