1,4-Diethylpiperazine

Base Information

• Chemical Name: 1,4-Diethylpiperazine
• CAS No.: 6483-50-7
• Molecular Formula: C8H18N2
• Molecular Weight: 142.244
• Hs Code.: 29335995
• European Community (EC) Number: 229-341-5
• DSSTox Substance ID: DTXSID5073373
• Nikkaji Number: J225.148E
• Wikidata: Q72462121
• Mol file: 6483-50-7.mol

Synonyms:1,4-Diethylpiperazine;6483-50-7;Piperazine, 1,4-diethyl-;1,4-DIethyl PIPERAZINE;EINECS 229-341-5;1,4-Diethylpiperazine #;SCHEMBL84808;DTXSID5073373;AMY10598;MFCD00126900;AKOS015963429;AS-57604;CS-0331491;L10057;A867816

Chemical Property of 1,4-Diethylpiperazine

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Vapor Pressure: 0.714mmHg at 25°C
• Refractive Index: 1.453-1.455
• Boiling Point: 185 °C at 760 mmHg
• PKA: 8.20±0.10(Predicted)
• Flash Point: 58.1 °C
• PSA: 6.48000
• Density: 0.868 g/cm³
• LogP: 0.51960
• Storage Temp.: 2-8°C
• Solubility.: Soluble in methanol, toluene.
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 142.146998583
• Heavy Atom Count: 10
• Complexity: 73.3

Purity/Quality:

99% ^*data from raw suppliers

DEPP,98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCN(CC1)CC
• Uses: 1,4-Diethylpiperazine is used as pharmaceutical intermediate.

Technology Process of 1,4-Diethylpiperazine

There total 22 articles about 1,4-Diethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

ethanol (64-17-5) + 2-(2-Aminoethylamino)ethanol (111-41-1) → 1,4-diethylpiperazine (6483-50-7)

Guidance literature:

With hydrogen; at 200 ℃; for 6h; under 7500.75 - 60006 Torr; Autoclave; Inert atmosphere;

Reference yield: 55.0%

piperazine (110-85-0) + chloroethane (75-00-3) → 4-ethylpiperazine (5308-25-8) + 1,4-diethylpiperazine (6483-50-7)

Guidance literature:

Reference yield: 47.0%

piperazine (110-85-0) + ethanol (64-17-5) → 1,4-diethylpiperazine (6483-50-7)

Guidance literature:

With Ru on activatedcarbon cloth; activatedcarbon cloth; In aq. phosphate buffer; at 60 ℃; for 10h; pH=8.5; Electrochemical reaction;

DOI:10.1039/c9gc03747k

upstream raw materials:

piperazine

potassium ethyl sulfate

sodium ethyl sulfate

ethyl iodide

Refernces

• 1、 Enyong, Arrey B.,Moasser, Bahram. "Ruthenium-catalyzed N-alkylation of amines with alcohols under mild conditions using the borrowing hydrogen methodology". . p. 7553 - 7563. Retrieved 2014/09/17.
• 2、 -. "METHOD FOR PRODUCING N-MONOALKYL-SUBSTITUTED ALKYLENE AMINE". Page/Page column 8. . Retrieved 2010/02/11.