2-(2-Pyridyl)benzimidazole

Base Information

• Chemical Name: 2-(2-Pyridyl)benzimidazole
• CAS No.: 1137-68-4
• Molecular Formula: C12H9N3
• Molecular Weight: 195.224
• Hs Code.: 29333999
• European Community (EC) Number: 214-508-7
• NSC Number: 110942,32814
• DSSTox Substance ID: DTXSID50150529
• Nikkaji Number: J2.864.996G,J203.388G
• Wikidata: Q72504623
• ChEMBL ID: CHEMBL72683
• Mol file: 1137-68-4.mol

Synonyms:2-pyridin-2-yl-1H-benzoimidazole

Chemical Property of 2-(2-Pyridyl)benzimidazole

Chemical Property:

• Appearance/Colour: Yellow to brown powder
• Vapor Pressure: 1.51E-07mmHg at 25°C
• Melting Point: 218-220 °C(lit.)
• Refractive Index: 1.699
• Boiling Point: 428.496 °C at 760 mmHg
• PKA: pK1:5.58(+1) (25°C,μ=0.16)
• Flash Point: 206.767 °C
• PSA: 41.57000
• Density: 1.271 g/cm³
• LogP: 2.62490
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water.
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 195.079647300
• Heavy Atom Count: 15
• Complexity: 219

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Pyridyl)benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 24/25-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)NC(=N2)C3=CC=CC=N3
• Uses: 2-(2-Pyridyl)benzimidazole was used as a chelating fluorescent ligand in the synthesis of cobalt(II) complex. It was also used in the preparation of (H(2)L(1))(2)[Ru(III)Cl(4)(CH(3)CN)(2)](2)[Ru(IV)Cl(4)(CH(3)CN)(2)]·2Cl·6H(2)O complex.

Technology Process of 2-(2-Pyridyl)benzimidazole

There total 34 articles about 2-(2-Pyridyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pyridine-2-carbaldehyde (1121-60-4) + 1,2-diamino-benzene (95-54-5) → 2-(2'-pyridyl)benzimidazole (1137-68-4)

Guidance literature:

With ammonium peroxydisulfate; sodium dodecyl-sulfate; In water; at 25 ℃; for 0.166667h; Micellar solution;

DOI:10.1039/c000047g

Reference yield: 99.0%

2-Hydroxymethylpyridine (586-98-1) + 1,2-diamino-benzene (95-54-5) → 2-(2'-pyridyl)benzimidazole (1137-68-4)

Guidance literature:

With [RuCl(CO)(PPh₃)(PNS-Me)]; potassium hydroxide; In toluene; at 100 ℃; for 24h; Catalytic behavior;

DOI:10.1039/c4dt00006d

Reference yield: 93.0%

2-(Aminomethyl)pyridine (3731-51-9) + 1,2-diamino-benzene (95-54-5) → 2-(2'-pyridyl)benzimidazole (1137-68-4)

Guidance literature:

With Al cations incorporated into the Si framework; open air; In neat (no solvent); at 100 ℃; for 15h; Green chemistry;

DOI:10.1039/d1gc02627e

upstream raw materials:

α-picoline

1,2-diamino-benzene

pyridine-2-carbaldehyde

2-Picolinic acid

Downstream raw materials:

1-benzyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole

C₁₉H₁₄BrN₃

[Cu(2-(2-pyridyl)benimidazole)(5-hydroxy-1,3-benzenedicarboxylate)]*H₂O

[Cd(5-hydroxyisophthalic acid)(2-(2-pyridyl)benzimidazole)]_n

Refernces

• 1、 Aliyan, Hamid,Fazaeli, Razieh,Fazaeli, Nahid,Mssah, Ahmad Reza,Naghash, Hamid Javaherian,Alizadeh, Mohammad,Emami, Ginous. "Facile route for the synthesis of benzothiazoles and benzimidazoles in the presence of tungstophosphoric acid impregnated zirconium phosphate under solvent-free conditions". . p. 202 - 207. Retrieved 2009.
• 2、 Fazlinia, Abbas,Sheikh, Setareh. "Preparation of 2-Arylbenzimidazole derivatives using CuO nanoparticles /H2O2 system". . p. 126 - 130. Retrieved 2018.
• 3、 Dayan, Osman,Demirmen, Selin,?zdemir, Namik. "Heteroleptic ruthenium(II) complexes of 2-(2-pyridyl)benzimidazoles: A study of catalytic efficiency towards transfer hydrogenation of acetophenone". . p. 926 - 932. Retrieved 2015.
• 4、 Jafarpour, Maasoumeh,Rezaeifard, Abdolreza,Ghahramaninezhad, Mahboube,Tabibi, Tooba. "Reusable α-MoO3 nanobelts catalyzes the green and heterogeneous condensation of 1,2-diamines with carbonyl compounds". . p. 2087 - 2095. Retrieved 2013.
• 5、 Ichikawa,Hisano. "Acidic properties of benzimidazoles and substituent effects. II. The substituent effect on the imidazole formation from p-substituted o-phenylenediamines and on the acid dissociation of the benzimidazoles". . p. 358 - 361. Retrieved 1977.
• 6、 Sinha, Soumalya,Berdichevsky, Ellan K.,Warren, Jeffrey J.. "Electrocatalytic CO2 reduction using rhenium(I) complexes with modified 2-(2'-pyridyl)imidazole ligands". . p. 63 - 68. Retrieved 2017.
• 7、 Du, Bin,Wang, Lei,Wu, HongBin,Yang, Wei,Zhang, Yong,Liu, RanSheng,Sun, MingLiang,Peng, Junbiao,Cao, Yong. "High-efficiency electrophosphorescent copolymers containing charged iridium complexes in the side chains". . p. 7432 - 7442. Retrieved 2007.
• 8、 Walter,Freiser. "-". . p. 217,218. Retrieved 1954.
• 9、 Samanta, Partha Kumar,Banerjee, Rumeli,Richards, Ryan M.,Biswas, Papu. "Mesoporous silica supported ytterbium as catalyst for synthesis of 1,2-disubstituted benzimidazoles and 2-substituted benzimidazoles". . . Retrieved 2018.
• 10、 Cape, Jonathan L.,Bowman, Michael K.,Kramer, David M.. "Reaction intermediates of quinol oxidation in a photoactivatable system that mimics electron transfer in the cytochrome bc1 complex". . p. 4208 - 4215. Retrieved 2005.