Tirofiban hydrochloride

Base Information

• Chemical Name: Tirofiban hydrochloride
• CAS No.: 150915-40-5
• Molecular Formula: C22H36N2O5S^.HCl^.H2O
• Molecular Weight: 495.08
• European Community (EC) Number: 682-504-6
• UNII: 6H925F8O5J
• DSSTox Substance ID: DTXSID5048635
• Wikidata: Q27108448
• NCI Thesaurus Code: C47759
• RXCUI: 253202
• Metabolomics Workbench ID: 53485
• ChEMBL ID: CHEMBL3189072
• Mol file: 150915-40-5.mol

Synonyms:Aggrastat;Agrastat;L 700,462;L 700462;L-700,462;L-700462;L700,462;MK 383;MK-383;N-(butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine;tirofiban;tirofiban hydrochloride;tirofiban hydrochloride monohydrate

Chemical Property of Tirofiban hydrochloride

Chemical Property:

• Appearance/Colour: white solid
• Melting Point: 135-137 °C
• Boiling Point: 611.7 °C at 760 mmHg
• Flash Point: 323.7 °C
• PSA: 122.34000
• Density: ==
• LogP: 5.48870
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO: >12mg/mL at warmed to 60°C
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 14
• Exact Mass: 494.2217358
• Heavy Atom Count: 32
• Complexity: 579

Purity/Quality:

99% ^*data from raw suppliers

Tirofiban, Hydrochloride Hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.O.Cl
• Isomeric SMILES: CCCCS(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.O.Cl
• Recent ClinicalTrials: Clinical Trial to Evaluate the Safety of Continuous IV Tirofiban in Acute Ischemic Stroke
• Recent EU Clinical Trials: RANDOMIZED MULTI-CENTER CLINICAL TRIAL TO ASSESS THE EFFECTIVENESS AND SAFETY OF TIROFIBAN VERSUS INTRAVENOUS ASPIRIN IN PATIENTS WITH ACUTE ISCHEMIC STROKE SECONDARY TO TANDEM INJURY, SUBJECT TO RECANALIZATION THERAPY THROUGH THROUGH ENDOVASCULAR TREATMENT
• Uses: Acute coronary syndrome (angina pectoris, myocardial infarction, surgery hydrant). Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. It can prevent platelet aggregation and thrombosis. A specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. An antithrombotic used in the treatment of unstable angina Tirofiban is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Tirofiban is an antithrombotic used in the treatment of unstable angina. Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.

Technology Process of Tirofiban hydrochloride

There total 1 articles about Tirofiban hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-n-butylsulfonyl-O-(4-(pyridin-4-yl)but-3-yn-1-yl)-L-tyrosine → tirofiban hydrochloride monohydrate (150915-40-5)

Guidance literature:

N-n-butylsulfonyl-O-(4-(pyridin-4-yl)but-3-yn-1-yl)-L-tyrosine; With 5%-palladium/activated carbon; hydrogen; acetic acid; at 60 ℃; for 5h; Autoclave;

With hydrogenchloride; In Isopropyl acetate; water; at 20 ℃; for 5h;

Refernces