2,4-DICHLORO-6-NITROANISOLE

Base Information

• Chemical Name: 2,4-DICHLORO-6-NITROANISOLE
• CAS No.: 37138-82-2
• Molecular Formula: C7H5 Cl2 N O3
• Molecular Weight: 222.028
• Hs Code.: 2909309090
• Mol file: 37138-82-2.mol

Synonyms:1,5-Dichloro-2-methoxy-3-nitrobenzene;2-Nitro-4,6-dichloroanisole

Chemical Property of 2,4-DICHLORO-6-NITROANISOLE

Chemical Property:

• Vapor Pressure: 0.00218mmHg at 25°C
• Boiling Point: 299°Cat760mmHg
• Flash Point: 134.6°C
• PSA: 55.05000
• Density: 1.488g/cm³
• LogP: 3.43340

Purity/Quality:

99%, ^*data from raw suppliers

2,4-DICHLORO-6-NITROANISOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DICHLORO-6-NITROANISOLE

There total 15 articles about 2,4-DICHLORO-6-NITROANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.6%

1,3-dichloro-4-methoxybenzene (553-82-2) → 2-methoxy-3,5-dichloronitrobenzene (37138-82-2) + 2,4-dichloro-6-nitrophenol (609-89-2) + 2,4-dicloro-5-nitroanisole (85829-14-7)

Guidance literature:

With nitric acid; In sulfuric acid; at 25 ℃; Rate constant; Product distribution; various acid concentrations;

DOI:10.1039/P29830000075

Reference yield: 12.1%

1,3-dichloro-4-methoxybenzene (553-82-2) → 2-methoxy-3,5-dichloronitrobenzene (37138-82-2) + 2,4-dicloro-5-nitroanisole (85829-14-7)

Guidance literature:

With nitric acid; In chloroform; for 1h;

DOI:10.1039/P29830000075

Reference yield:

1,3-dichloro-4-methoxybenzene (553-82-2) → 2-methoxy-3,5-dichloronitrobenzene (37138-82-2)

Guidance literature:

With nitric acid; at 2 ℃;

upstream raw materials:

1,3-dichloro-4-methoxybenzene

2,3,5-trichloronitrobenzene

sodium methylate

1,5-dichloro-2,3-dinitrobenzene

Downstream raw materials:

[2-(3,5-Dichloro-2-methoxy-phenoxy)-ethyl]-diethyl-amine

[2-(3,5-Dichloro-2-methoxy-phenoxy)-ethyl]-dimethyl-amine

3,5-dichloro-2-methoxyphenol

4,6-dichloro-2,3-dinitro-anisole

Refernces

• 1、 Bloomfield, Colin,Manglik, Ajay K.,Moodie, Roy B.,Schofield, Kenneth,Tobin, Geoffrey D.. "Electrophilic Aromatic Substitution. Part 28. The Mechanism of Nitration of Some 4-Substituted Anisoles and Phenols, and of Rearrangement of the Intermediate 4-Nitro-4-substituted-cyclohexa-2,5-dienones". . p. 75 - 82. Retrieved 2007/10/02.