Benzenemethanol, a-[[(4-methylphenyl)sulfonyl]methyl]-

Base Information

• Chemical Name: Benzenemethanol, a-[[(4-methylphenyl)sulfonyl]methyl]-
• CAS No.: 14799-10-1
• Molecular Formula: C₁₅H₁₆O₃S
• Molecular Weight: 276.356
• Mol file: 14799-10-1.mol

Synonyms:

Chemical Property of Benzenemethanol, a-[[(4-methylphenyl)sulfonyl]methyl]-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, a-[[(4-methylphenyl)sulfonyl]methyl]-

There total 51 articles about Benzenemethanol, a-[[(4-methylphenyl)sulfonyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phenyl-2-tosylethanone (31378-03-7) → 2-hydroxy-2-phenylethyl 4-methylphenyl sulfone (71899-75-7,71899-81-5,14799-10-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2017.01.030

Reference yield: 99.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 2-hydroxy-2-phenylethyl 4-methylphenyl sulfone (71899-75-7,71899-81-5,14799-10-1)

Guidance literature:

With pyridine; iodine; oxygen; In acetonitrile; at 70 ℃; for 7h; Reagent/catalyst; Solvent; Temperature; Sealed tube; Green chemistry;

DOI:10.1002/adsc.201700772

Reference yield: 97.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + p-toluene sulfinic acid (536-57-2) → 2-hydroxy-2-phenylethyl 4-methylphenyl sulfone (71899-75-7,71899-81-5,14799-10-1)

Guidance literature:

styrene; p-toluene sulfinic acid; With pyridine; oxygen; In chloroform; at 60 ℃; for 1.33333h; under 760.051 Torr; Schlenk technique;

In chloroform; at 60 ℃; for 0.5h; under 760.051 Torr; Schlenk technique;

DOI:10.1002/anie.201301634

upstream raw materials:

benzaldehyde

Methyl p-tolyl sulfone

styrene oxide

sodium 4-methylbenzenesulfinate

Downstream raw materials:

1-methyl-4-((2-phenylallyl)sulfonyl)benzene

1-methyl-4-[(E)-2-phenylethenesulfonyl]benzene

Refernces

• 1、 Wang, Yanjie,Zhao, Yuhan,Cai, Changqun,Wang, Lingyun,Gong, Hang. "Dioxygen-Triggered Oxosulfonylation/Sulfonylation of Terminal Olefins toward β-Keto Sulfones/Sulfones". . p. 8296 - 8301. Retrieved 2021/11/13.
• 2、 Bu, Mei-Jie,Cai, Chun,Gallou, Fabrice,Lipshutz, Bruce H.. "PQS-enabled visible-light iridium photoredox catalysis in water at room temperature". supporting information. p. 1233 - 1237. Retrieved 2018/03/26.