Δ2-Cefditoren Pivoxil

Base Information

• Chemical Name: Δ2-Cefditoren Pivoxil
• CAS No.: 148774-47-4
• Molecular Formula: C25H28N6O7S3
• Molecular Weight: 620.72
• Mol file: 148774-47-4.mol

Synonyms:

Chemical Property of Δ2-Cefditoren Pivoxil

Chemical Property:

Purity/Quality:

≧95%, ^*data from raw suppliers

Δ2-CefditorenPivoxil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Δ2-Cefditoren Pivoxil is a metabolite of Cefditoren Pivoxil (C242700), an antibacterial, third generation cephalosporin.

Technology Process of Δ2-Cefditoren Pivoxil

There total 2 articles about Δ2-Cefditoren Pivoxil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodomethyl pivaloate (53064-79-2) + (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid → (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 2,2-dimethylpropionyloxymethyl ester (148774-47-4)

Guidance literature:

In N,N-dimethyl-formamide; at -45 - -40 ℃;

Reference yield:

(6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (155723-02-7) → (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 2,2-dimethylpropionyloxymethyl ester (148774-47-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N,O-bis-(trimethylsilyl)-acetamide; tributyl-amine / dichloromethane / 20 - 30 °C / Inert atmosphere

2: triethylamine / water; tetrahydrofuran / 3 h / 0 - 5 °C / pH 8.5

3: N,N-dimethyl-formamide / -45 - -40 °C

With N,O-bis-(trimethylsilyl)-acetamide; tributyl-amine; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

(6R,7R)-7-amino-3-[(1Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

iodomethyl pivaloate

Refernces