Acetamide, N-2-butenyl-2,2,2-trifluoro-N-(phenylmethyl)-, (E)-

Base Information

• Chemical Name: Acetamide, N-2-butenyl-2,2,2-trifluoro-N-(phenylmethyl)-, (E)-
• CAS No.: 148943-71-9
• Molecular Formula: C13H14F3NO
• Molecular Weight: 257.255
• Mol file: 148943-71-9.mol

Synonyms:

Chemical Property of Acetamide, N-2-butenyl-2,2,2-trifluoro-N-(phenylmethyl)-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, N-2-butenyl-2,2,2-trifluoro-N-(phenylmethyl)-, (E)-

There total 2 articles about Acetamide, N-2-butenyl-2,2,2-trifluoro-N-(phenylmethyl)-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(E)-but-2-enol (504-61-0,542-72-3) + N-benzyl-2,2,2-trifluoroacetamide (7387-69-1) → N-Benzyl-N-((E)-but-2-enyl)-2,2,2-trifluoro-acetamide (148943-71-9)

Guidance literature:

With tributylphosphine; diamide; In benzene; for 24h; Ambient temperature;

DOI:10.1246/cl.1994.539

Reference yield: 73.0%

(E)-1-Bromo-2-butene (4784-77-4,39616-19-8,29576-14-5) + N-benzyl-2,2,2-trifluoroacetamide (7387-69-1) → N-Benzyl-N-((E)-but-2-enyl)-2,2,2-trifluoro-acetamide (148943-71-9)

Guidance literature:

N-benzyl-2,2,2-trifluoroacetamide; With sodium hydride; sodium iodide; In tetrahydrofuran; mineral oil; for 1h; Inert atmosphere;

(E)-1-Bromo-2-butene; In tetrahydrofuran; mineral oil; for 16h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201806295

Reference yield: 100.0%

N-Benzyl-N-((E)-but-2-enyl)-2,2,2-trifluoro-acetamide (148943-71-9) → benzyl crotyl amine (107733-62-0)

Guidance literature:

With sodium hydroxide; In methanol; Ambient temperature;

DOI:10.1246/cl.1994.539

upstream raw materials:

(E)-but-2-enol

N-benzyl-2,2,2-trifluoroacetamide

(E)-1-Bromo-2-butene

Downstream raw materials:

benzyl crotyl amine

2-methyl-1-phenylbut-3-en-1-amine

C₁₅H₂₆N₃OP

C₁₅H₂₆N₃OP

Refernces

• 1、 Manabe, Shino. "Aza-[2,3] sigmatropic rearrangement of phosphoramides". . p. 2491 - 2492. Retrieved 2007/10/03.
• 2、 Tsunoda, Tetsuto,Yamamiya, Yoshiko,Ito, Sho. "1,1′-(azodicarbonyl)dipiperidine-tributylphosphine, a new reagent system for mitsunobu reaction". . p. 1639 - 1642. Retrieved 2007/10/02.