D-Valine, N-benzoyl-, methyl ester

Base Information

• Chemical Name: D-Valine, N-benzoyl-, methyl ester
• CAS No.: 1492-13-3
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Mol file: 1492-13-3.mol

Synonyms:

Chemical Property of D-Valine, N-benzoyl-, methyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Valine, N-benzoyl-, methyl ester

There total 48 articles about D-Valine, N-benzoyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-Valine methyl ester (4070-48-8) + benzoic acid (65-85-0,8013-63-6) → N-benzoyl-L-valine methyl ester (1492-13-3,14599-03-2,92077-72-0,10512-91-1)

Guidance literature:

With dmap; 2-chloro-1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecyl)pyridinium trifluoromethanesulfonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2008.09.016

Reference yield: 97.0%

L-valine methylester hydrochloride (6306-52-1) + benzoyl chloride (98-88-4) → N-benzoyl-L-valine methyl ester (1492-13-3,14599-03-2,92077-72-0,10512-91-1)

Guidance literature:

With potassium carbonate; In chloroform; for 3h; Heating;

DOI:10.1002/jhet.5570410109

Reference yield: 94.0%

L-Valine methyl ester (4070-48-8) + benzaldehyde (100-52-7) → N-benzoyl-L-valine methyl ester (1492-13-3,14599-03-2,92077-72-0,10512-91-1)

Guidance literature:

With tert.-butylhydroperoxide; In 1,4-dioxane; at 60 ℃; for 8h; Inert atmosphere;

DOI:10.1002/cctc.202001041

upstream raw materials:

diazomethane

(2R)-2-(benzoylamino)-3-methylbutyric acid

methanol

2-phenyl-4-iso-propyl-4H-oxazolin-5-one

Downstream raw materials:

(2R)-2-(benzoylamino)-3-methylbutyric acid hydrazide

N-benzyl-L-valinol

N-benzoyl-valinal

(S)-N-(1-(methoxy(methyl)amino)-3-methyl-1-oxobutan-2-yl)benzamide

Refernces

• 1、 Nikitas, Nikolaos F.,Apostolopoulou, Mary K.,Skolia, Elpida,Tsoukaki, Anna,Kokotos, Christoforos G.. "Photochemical Activation of Aromatic Aldehydes: Synthesis of Amides, Hydroxamic Acids and Esters". . p. 7915 - 7922. Retrieved 2021/05/03.
• 2、 Bai, Shao-Tao,Bheeter, Charles B.,Reek, Joost N. H.. "Hydrogen Bond Directed ortho-Selective C?H Borylation of Secondary Aromatic Amides". supporting information. p. 13039 - 13043. Retrieved 2019/07/31.