m-PEG2-acid

Base Information

• Chemical Name: m-PEG2-acid
• CAS No.: 149577-05-9
• Molecular Formula: C6H12O4
• Molecular Weight: 148.159
• Hs Code.: 2918990090
• Mol file: 149577-05-9.mol

Synonyms:

Chemical Property of m-PEG2-acid

Chemical Property:

• Boiling Point: 244.2±20.0 °C(Predicted)
• PKA: 4.28±0.10(Predicted)
• PSA: 55.76000
• Density: 1.098±0.06 g/cm3(Predicted)
• LogP: 0.12410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(2-methoxyethoxy)propanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: m-PEG2-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Technology Process of m-PEG2-acid

There total 4 articles about m-PEG2-acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-methoxy-ethanol (109-86-4,95507-80-5) + ethyl acrylate (140-88-5,9003-32-1) → 3-(2-methoxyethyloxy)propionic acid (149577-05-9,125220-94-2)

Guidance literature:

2-methoxy-ethanol; ethyl acrylate; With potassium carbonate; In acetonitrile; at 90 ℃; for 24h;

With sodium hydroxide; In ethanol; water; at 90 ℃; for 1h;

DOI:10.1016/j.bmc.2016.03.056

Reference yield:

3-(2-methoxy-ethoxy)-propionic acid methyl ester → 3-(2-methoxyethyloxy)propionic acid (149577-05-9,125220-94-2)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃; for 16h;

Reference yield:

C10H20O4 → 3-(2-methoxyethyloxy)propionic acid (149577-05-9,125220-94-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

2-methoxy-ethanol

ethyl acrylate

Downstream raw materials:

6-fluoro-2-(4'-N-(2''-(2''-methoxyethoxy)acetamido)phenyl)benzothiazole

5-(4-{1-[5-(2-methoxy-ethoxymethyl)-[1,2,4]oxadiazol-3-yl]-1,2-dimethyl-propyl}-phenyl)-pyrimidin-2-ylamine

Refernces

• 1、 -. "2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS". Page/Page column 67. . Retrieved 2017/02/09.
• 2、 -. "ONIUM SALT, LIQUID COMPOSITION CONTAINING SAID ONIUM SALT AND CELLULOSE, AND CELLULOSE RECOVERY METHOD". Paragraph 0119; 0120; 0121. . Retrieved 2016/02/19.