1-(Pentanoylamino)cyclopentane-1-carboxylic acid

Base Information

• Chemical Name: 1-(Pentanoylamino)cyclopentane-1-carboxylic acid
• CAS No.: 15026-80-9
• Molecular Formula: C11H19NO3
• Molecular Weight: 213.277
• DSSTox Substance ID: DTXSID50587391
• Nikkaji Number: J2.525.486D
• Wikidata: Q82479798
• Mol file: 15026-80-9.mol

Synonyms:15026-80-9;1-(Pentanoylamino)cyclopentane-1-carboxylic acid;N-pentanoylaminocyclopentane-1-carboxylic acid;n-pentanoyl cycloleucine;SCHEMBL500447;DTXSID50587391;HPHUHSPLHSCYJB-UHFFFAOYSA-N;1-Valeramidocyclopentanecarboxylic acid;AKOS009267416;MCULE-7418879542;DB-371599;1-[(1-oxopentyl)amino]-cyclopentanecarboxylic acid;Z364354406

Chemical Property of 1-(Pentanoylamino)cyclopentane-1-carboxylic acid

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 213.13649347
• Heavy Atom Count: 15
• Complexity: 244

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(=O)NC1(CCCC1)C(=O)O

Technology Process of 1-(Pentanoylamino)cyclopentane-1-carboxylic acid

There total 6 articles about 1-(Pentanoylamino)cyclopentane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

n-valeryl chloride (638-29-9) + 1-amino-1-cyclopentanecarboxylic acid (52-52-8) → N-pentanoylaminocyclopentane-1-carboxylic acid (15026-80-9)

Guidance literature:

With sodium hydroxide; In water; toluene; at 0 - 10 ℃; for 2h;

DOI:10.1515/HC.2006.12.5.323

Reference yield: 68.0%

1-aminocyclopentanecarboxylic acid hydrochloride (92398-48-6) + n-valeryl chloride (638-29-9) → N-pentanoylaminocyclopentane-1-carboxylic acid (15026-80-9)

Guidance literature:

1-aminocyclopentanecarboxylic acid hydrochloride; n-valeryl chloride; With sodium hydroxide; tetrabutylammomium bromide; In water; toluene; at 0 - 5 ℃; for 2h;

In water; Product distribution / selectivity; Acidic aqueous solution;

Reference yield:

1-cyano-1-n-pentanoylaminocyclopentane (194984-24-2) → N-pentanoylaminocyclopentane-1-carboxylic acid (15026-80-9)

Guidance literature:

With hydrogenchloride; at 55 - 60 ℃; for 2h;

DOI:10.1080/00397910701471279

upstream raw materials:

n-valeryl chloride

1-amino-1-cyclopentanecarboxylic acid

1-cyano-1-n-pentanoylaminocyclopentane

1-aminocyclopentanecarbonitrile hydrochloride

Downstream raw materials:

1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

2-(n-butyl)-3-[2'-(1,3-oxazolin-4,4-dimethyl)-biphenyl-4-ylmethyl]-4-oxo-1,3-diazaspiro[4.4]non-1-ene-4-one

Refernces

• 1、 Rao, Korrapati V. V. Prasada,Dandala, Ramesh,Handa, Vijay K.,Rao, Inti V. Subramanyeswara,Rani, Ananta,Naidu, Andra. "Improved methods for the synthesis of irbesartan, an antihypertensive active pharmaceutical ingredient". . p. 2897 - 2905. Retrieved 2008/02/13.
• 2、 -. "AN IMPROVED PROCESS FOR PREPARATION OF IRBESARTAN". Page/Page column 20; 24-25. . Retrieved 2008/06/13.