2-Pyridinecarboxylic acid, 5-phenyl-, 1-oxide

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 5-phenyl-, 1-oxide
• CAS No.: 150461-42-0
• Molecular Formula: C12H9NO3
• Molecular Weight: 215.208
• Mol file: 150461-42-0.mol

Synonyms:

Chemical Property of 2-Pyridinecarboxylic acid, 5-phenyl-, 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinecarboxylic acid, 5-phenyl-, 1-oxide

There total 3 articles about 2-Pyridinecarboxylic acid, 5-phenyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-phenylpicolinate (65117-74-0) → 2-carboxy-5-phenylpyridine N-oxide (150461-42-0)

Guidance literature:

With dihydrogen peroxide; acetic acid; In water; at 80 ℃; for 5h;

DOI:10.1002/chem.201304773

Reference yield:

5-chloropicolinic acid (86873-60-1) → 2-carboxy-5-phenylpyridine N-oxide (150461-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C

1.2: 1 h / 20 °C

2.1: caesium carbonate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 110 °C / Sealed tube; Inert atmosphere

3.1: dihydrogen peroxide; acetic acid / water / 5 h / 80 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; oxalyl dichloride; dihydrogen peroxide; palladium diacetate; caesium carbonate; acetic acid; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;

DOI:10.1002/chem.201304773

Reference yield:

ethyl 5-chloropyridine-2-carboxylate (128072-93-5) → 2-carboxy-5-phenylpyridine N-oxide (150461-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane / 110 °C / Sealed tube; Inert atmosphere

2: dihydrogen peroxide; acetic acid / water / 5 h / 80 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dihydrogen peroxide; palladium diacetate; caesium carbonate; acetic acid; In 1,4-dioxane; water;

DOI:10.1002/chem.201304773

upstream raw materials:

ethyl 5-chloropyridine-2-carboxylate

ethyl 5-phenylpicolinate

5-chloropicolinic acid

Downstream raw materials:

5-phenyl-2-(p-tolyl)pyridine N-oxide

Refernces