L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-

Base Information

• Chemical Name: L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-
• CAS No.: 2410-93-7
• Molecular Formula: C20H21 N7 O6
• Molecular Weight: 455.42
• Hs Code.: 2933599550
• Mol file: 2410-93-7.mol

Synonyms:Glutamicacid, N-[p-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-,L- (7CI,8CI); Glutamic acid,N-[p-[[(2-amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]- (6CI);L-Glutamic acid,N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-(9CI); 10-Methylfolic acid; 10-Methylpteroylglutamic acid; Methopterin;Methopterine; N10-Methylfolic acid; N10-Methylpteroylglutamic acid; NSC 107144

Chemical Property of L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 3.49±0.10(Predicted)
• Flash Point: °C
• PSA: 204.75000
• Density: 1.61g/cm³
• LogP: 1.36390
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMF (Slightly, Heated), DMSO (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Methopterine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-

There total 6 articles about L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid (59-05-2) → N10-methylfolic acid (2410-93-7)

Guidance literature:

With sodium hydroxide; In water; for 4.5h; Heating;

Reference yield: 44.0%

folate (65165-92-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 10-methylfolic acid (2410-93-7,96738-72-6)

Guidance literature:

With sodium cyanoborohydride; In water; for 20h; pH 6.5;

DOI:10.1021/jm00344a014

Reference yield:

N-(4-aminobenzoyl)-L-glutamic acid (4271-30-1,532-63-8) → N10-methylfolic acid (2410-93-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite; aqueous hydrochloric acid; aqueous potassium iodide solution / Diazotization

2: aq. NaOH solution; copper / 125 °C

With hydrogenchloride; sodium hydroxide; copper; potassium iodide; sodium nitrite;

DOI:10.1021/ja01185a081

upstream raw materials:

2,5,6-triamino-3,4-dihydro-4-pyrimidinone

2,3-dibromopropanal

p-(N-methylamino)benzoyl-L-glutamic acid

N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

Downstream raw materials:

N-(ambo-5-formyl-10-methyl-5,6,7,8-tetrahydro-pteroyl)-L-glutamic acid

N-(3'-chloro-10-methyl-pteroyl)-L-glutamic acid

N-(3',5'-dichloro-10-methyl-pteroyl)-L-glutamic acid

10-methyl-5-(uracil-5-ylmethyl)<6-2H¹>tetrahygropteroylglutamic acid

Refernces

• 1、 Temple, Carroll,Bennett, L. Lee,Rose, Jerry D.,Elliott, Robert D.,Montgomery, John A.,Mangum, John H.. "Synthesis of Pseudo Cofactor Analogues as Potential Inhibitors of the Folate Enzymes". . p. 161 - 166. Retrieved 2007/10/02.