3,5-Dimethylpiperidine

Base Information

• Chemical Name: 3,5-Dimethylpiperidine
• CAS No.: 35794-11-7
• Molecular Formula: C7H15N
• Molecular Weight: 113.203
• Hs Code.: 29339900
• European Community (EC) Number: 252-730-6
• DSSTox Substance ID: DTXSID80865790
• Nikkaji Number: J39.740G
• Wikipedia: 3,5-Dimethylpiperidine
• Mol file: 35794-11-7.mol

Synonyms:3,5-Dimethylpiperidine;35794-11-7;Piperidine, 3,5-dimethyl-;3,5-Lupetidine;MFCD00005996;3alpha,5beta-Dimethylpiperidine;EINECS 252-730-6;3,5-Dimethylpiperidine, cis and trans;MFCD09832871;32452-46-3;3,5-Dimethylpiperidine, cis + trans;3,5-dimethylpiperdine;3,5 dimethylpiperidine;3,5-dimethylpiperadine;3.5-Dimethylpiperidine;Hexahydro-3,5-lutidine;3,5-dimethyl-piperidine;SCHEMBL25874;AMY3386;DTXSID80865790;1400908-06-6;(3R,5S)-3,5-dimethyl piperidine;AKOS000118824;AKOS016039390;CS-W011255;SB33653;SB41077;CS-17341;SY023084;D1411;FT-0614704;FT-0614705;EN300-19582;D77718;A822982;SR-01000944739;SR-01000944739-1;W-106653;F2190-0337;Z104474332

Chemical Property of 3,5-Dimethylpiperidine

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Vapor Pressure: 5.93mmHg at 25°C
• Refractive Index: n20/D 1.4454(lit.)
• Boiling Point: 141.2 °C at 760 mmHg
• PKA: 10.52±0.10(Predicted)
• Flash Point: 32.8 °C
• PSA: 12.03000
• Density: 0.794 g/cm³
• LogP: 1.58070
• Storage Temp.: Flammables area
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 113.120449483
• Heavy Atom Count: 8
• Complexity: 62.8

Purity/Quality:

99.9% ^*data from raw suppliers

3,5-Dimethylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1CC(CNC1)C
• Uses: Reactant for synthesis of: Substituted bisphenol A derivatives as β-amyloid peptide aggregation inhibitors1 MMP-13 selective isonipecotamide α-sulfone hydroxamates2 Gem-diamines for active organocatalysts for biodiesel production3 Benzimidazole inhibitors of the antigen receptor-mediated NF-κB4 Reactant for Mannich reactions to form Ru(II) complexes5 Reactant for synthesis of: Substituted bisphenol A derivatives as β-amyloid peptide aggregation inhibitors MMP-13 selective isonipecotamide α-sulfone hydroxamates Gem-diamines for active organocatalysts for biodiesel production Benzimidazole inhibitors of the antigen receptor-mediated NF-κB Reactant for Mannich reactions to form Ru(II) complexes

Technology Process of 3,5-Dimethylpiperidine

There total 12 articles about 3,5-Dimethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-Lutidine (591-22-0) → 3,5-dimethylpiperidine (35794-11-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; at 20 ℃; for 24h; under 760.051 Torr; Time;

Reference yield:

3,5-Lutidine (591-22-0) → (3S,5R)-3,5-dimethylpiperidine (14446-75-4,32410-46-1,32452-46-3,35794-11-7)

Guidance literature:

3,5-Lutidine; With potassium carbonate; at 150 ℃; for 5h; under 67506.8 Torr; Autoclave; Inert atmosphere;

In ethanol; hexane; at -10 - 20 ℃; for 1h; Reagent/catalyst; Autoclave; Inert atmosphere;

Reference yield:

cis-1-benzyl-3,5-dimethylpiperidine → (3S,5R)-3,5-dimethylpiperidine (14446-75-4,32410-46-1,32452-46-3,35794-11-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 40 ℃; for 24h; under 5171.62 Torr;

upstream raw materials:

3,5-dimethyl-piperidine-2,6-dione

meso-2,4-dimethylglutaric anhydride

3,5-Lutidine

methanol

Downstream raw materials:

2-(3,5-Dimethyl-piperidin-1-yl)-ethylamine

cis-(3RS,5SR)-3,5-dimethyl-1-(3-phenylprop-2-ynyl)piperidine

trans-(3RS,5RS)-3,5-dimethyl-1-(3-phenylprop-2-ynyl)piperidine

Refernces

• 1、 -. "PRODUCTION METHOD OF CYCLIC COMPOUND". Paragraph 0057; 0059; 0062-0064. . Retrieved 2021/05/05.
• 2、 -. "HYDROGENATION PROCESS". Page/Page column 27-28. . Retrieved 2020/01/24.