GADOTERIDOL RELATED COMPOUND B (50 MG) (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID, MONOGADOLINIUM SALT)

Base Information

• Chemical Name: GADOTERIDOL RELATED COMPOUND B (50 MG) (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID, MONOGADOLINIUM SALT)
• CAS No.: 112188-16-6
• Molecular Formula: C₁₄H₂₃GdN₄O₆
• Molecular Weight: 500.61
• Hs Code.: 2942000000
• Mol file: 112188-16-6.mol

Synonyms:Gadolinium,[1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-N1,N4,N7,N10,O1,O4,O7]-;1,4,7,10-Tetraazacyclododecane, gadolinium deriv.;1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, gadolinium complex; Gd-DO3A

Chemical Property of GADOTERIDOL RELATED COMPOUND B (50 MG) (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID, MONOGADOLINIUM SALT)

Chemical Property:

• Vapor Pressure: 7.68E-17mmHg at 25°C
• Boiling Point: 617.6°Cat760mmHg
• Flash Point: 327.3°C
• PSA: 142.14000
• Density: g/cm³
• LogP: -6.11220
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Des(2-Hydroxypropyl)Gadoteridol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Des(2-hydroxypropyl) Gadoteridol is a contrast imaging agent metabolite from Gadoteridol (G125900), used as an MRI contrast chelating agent.

Technology Process of GADOTERIDOL RELATED COMPOUND B (50 MG) (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID, MONOGADOLINIUM SALT)

There total 2 articles about GADOTERIDOL RELATED COMPOUND B (50 MG) (1,4,7,10-TETRAAZACYCLODODECANE-1,4,7-TRIACETIC ACID, MONOGADOLINIUM SALT) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

gadolinium(III) chloride hexahydrate + 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (114873-37-9) → [Gd(DO3A)] (112188-16-6)

Guidance literature:

With sodium hydroxide; In water; at 70 ℃; for 24h; pH=6 - 8;

DOI:10.1080/00397911.2014.977399

Reference yield:

gadolinium(III) chloride (10138-52-0) + 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (114873-37-9) → [Gd(DO3A)] (112188-16-6)

Guidance literature:

In water; room temp., pH 6-8;

upstream raw materials:

gadolinium(III) chloride

1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

Refernces

• 1、 Terreno, Enzo,Botta, Mauro,Fedeli, Franco,Mondino, Bruna,Milone, Luciano,Aime, Silvio. "Enantioselective recognition between chiral α-hydroxy-carboxylates and macrocyclic heptadentate lanthanide(III) chelates". . p. 4891 - 4897. Retrieved 2008/10/08.