2,6-DIFLUOROCINNAMIC ACID

Base Information

• Chemical Name: 2,6-DIFLUOROCINNAMIC ACID
• CAS No.: 152152-09-5
• Molecular Formula: C9H6F2O2
• Molecular Weight: 184.14000
• Mol file: 152152-09-5.mol

Synonyms:2,5-DIFLUORO-L-PHENYLALANINE;2,6-Difluorocinnamic acid;

Chemical Property of 2,6-DIFLUOROCINNAMIC ACID

Chemical Property:

• Vapor Pressure: 0.00306mmHg at 25°C
• PSA: 37.30000
• LogP: 2.06260

Purity/Quality:

99% ^*data from raw suppliers

2,6-Difluorocinnamicacid 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S36:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIFLUOROCINNAMIC ACID

There total 2 articles about 2,6-DIFLUOROCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(Z/E) methyl 3-(2,6-difluorophenyl)acrylate → (Z/E) 3-(2,6-difluorophenyl)acrylic acid (152152-09-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 3h;

DOI:10.1080/00397910701649023

Reference yield:

malonic acid (141-82-2) + 2,6-difluorobenzaldehyde (437-81-0) → (Z/E) 3-(2,6-difluorophenyl)acrylic acid (152152-09-5)

Guidance literature:

With piperidine; pyridine; at 90 - 105 ℃;

DOI:10.1016/j.bmc.2015.08.024

Reference yield: 60.0%

(Z/E) 3-(2,6-difluorophenyl)acrylic acid (152152-09-5) + C10H14F2OSi → (E)-4-(2,6-difluorophenyl)-1,1-difluorobut-3-en-2-ol

Guidance literature:

(Z/E) 3-(2,6-difluorophenyl)acrylic acid; C₁₀H₁₄F₂OSi; With tert-Butyl peroxybenzoate; manganese(III) triacetate dihydrate; at 70 ℃; for 14h; Inert atmosphere; Schlenk technique; Sealed tube;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 5 ℃; for 0.5h; Inert atmosphere; Cooling with ice; Sealed tube;

upstream raw materials:

malonic acid

2,6-difluorobenzaldehyde

Downstream raw materials:

C₃₀H₃₄F₂N₄O₂

C₉H₈F₂O

Refernces

• 1、 Sanchez, Lucina G.,Somanathan, Ratnasamy,Hellberg, Lars H.,Aguirre, Gerardo. "Synthesis of Z-N-alkenylformamides". . p. 45 - 53. Retrieved 2008/03/14.