Piperidin-1-ol

Base Information

• Chemical Name: Piperidin-1-ol
• CAS No.: 4801-58-5
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 2933399090
• European Community (EC) Number: 225-362-9
• UNII: 9ANQ5DB3A2
• DSSTox Substance ID: DTXSID9063611
• Nikkaji Number: J53.866C
• Wikipedia: N-Hydroxypiperidine
• Wikidata: Q6951371
• ChEMBL ID: CHEMBL277887
• Mol file: 4801-58-5.mol

Synonyms:1-hydroxypiperidine;N-hydroxypiperidine

Chemical Property of Piperidin-1-ol

Chemical Property:

• Vapor Pressure: 0.542mmHg at 25°C
• Melting Point: 37-39oC
• Refractive Index: 1.4550 (estimate)
• Boiling Point: 175.7°Cat760mmHg
• PKA: 14.19±0.20(Predicted)
• Flash Point: 84.9°C
• PSA: 23.47000
• Density: 1.07g/cm³
• LogP: 0.79940
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 101.084063974
• Heavy Atom Count: 7
• Complexity: 50

Purity/Quality:

99%, ^*data from raw suppliers

1-Hydroxypiperidine ≥96.0% (GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: C1CCN(CC1)O
• Uses: Base for Fmoc-based solid phase peptide synthesis1Light stabilizing agent2 Base for Fmoc-based solid phase peptide synthesisLight stabilizing agent

Technology Process of Piperidin-1-ol

There total 21 articles about Piperidin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

piperidine (110-89-4) → N-hydroxypiperidine (4801-58-5)

Guidance literature:

With 2-hydroxy-N,N,N-trimethyl ethanaminium peroxydisulfate; at 20 ℃; for 1h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1055/s-0036-1589089

Reference yield: 72.0%

3-(piperidin-1-yl)propionitrile (3088-41-3) → N-hydroxypiperidine (4801-58-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(01)01745-2

Reference yield: 63.0%

piperidin-1-yl benzoate (5542-49-4) → N-hydroxypiperidine (4801-58-5)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00556

upstream raw materials:

piperidine

N-ethylpiperidine N-oxide

Perbenzoic acid

ethyl piperidine-1-propionate

Downstream raw materials:

1-benzyloxycarbonyloxy-piperidine

N-Morpholinomethoxy-piperidin

diphenyl-(1-piperidin-1-yloxy-butoxy)-borane

piperidine

Refernces

• 1、 Dhanju, Sandeep,Crich, David. "Synthesis of N,N,O-Trisubstituted Hydroxylamines by Stepwise Reduction and Substitution of O-Acyl N,N-Disubstituted Hydroxylamines". . p. 1820 - 1823. Retrieved 2016/05/19.
• 2、 -. "Cyanine dyes". . . Retrieved 2008/06/13.