Technology Process of 1-Hexadecanol,
16,16'-[[(1S)-1-[(phenylmethoxy)methyl]-1,2-ethanediyl]bis(oxy)]bis[2,6,
10,14-tetramethyl-, (2S,2'S,6S,6'S,10R,10'R,14R,14'R)-
There total 28 articles about 1-Hexadecanol,
16,16'-[[(1S)-1-[(phenylmethoxy)methyl]-1,2-ethanediyl]bis(oxy)]bis[2,6,
10,14-tetramethyl-, (2S,2'S,6S,6'S,10R,10'R,14R,14'R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1039/c3ob27277j
- Guidance literature:
-
Multi-step reaction with 16 steps
1: imidazole / dimethylformamide
2: DIBAH
3: TfOH / diethyl ether
4: aq. HCl / tetrahydrofuran
5: pyridine
6: K2CO3 / dimethylformamide
7: m-CPBA / CH2Cl2
8: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
9: 86 percent / Na(Hg) / methanol
10: H2 / 10percent Pd/C / ethyl acetate
11: I2, Ph3P, imidazole / benzene
12: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
13: Li, EtNH2 / tetrahydrofuran / -78 °C
14: Et3N / CH2Cl2
15: 1.) NaH / 1.) DMSO, 2.) DMSO
16: aq. HCl / tetrahydrofuran
With
pyridine; 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; hydrogen; iodine; lithium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ethylamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39940000137
- Guidance literature:
-
Multi-step reaction with 17 steps
1: aq. HCl / tetrahydrofuran
2: imidazole / dimethylformamide
3: DIBAH
4: TfOH / diethyl ether
5: aq. HCl / tetrahydrofuran
6: pyridine
7: K2CO3 / dimethylformamide
8: m-CPBA / CH2Cl2
9: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
10: 86 percent / Na(Hg) / methanol
11: H2 / 10percent Pd/C / ethyl acetate
12: I2, Ph3P, imidazole / benzene
13: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
14: Li, EtNH2 / tetrahydrofuran / -78 °C
15: Et3N / CH2Cl2
16: 1.) NaH / 1.) DMSO, 2.) DMSO
17: aq. HCl / tetrahydrofuran
With
pyridine; 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; hydrogen; iodine; lithium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ethylamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39940000137
