2,2-Dimethylpropan-1-amine hydrochloride

Base Information

• Chemical Name: 2,2-Dimethylpropan-1-amine hydrochloride
• CAS No.: 15925-18-5
• Molecular Formula: C5H13N.ClH
• Molecular Weight: 123.626
• Hs Code.: 2921199090
• European Community (EC) Number: 821-077-4
• DSSTox Substance ID: DTXSID10497548
• Mol file: 15925-18-5.mol

Synonyms:15925-18-5;2,2-dimethylpropan-1-amine hydrochloride;2,2-DiMethyl-1-propanaMine hydrochloride;neopentylamine hydrochloride;2,2-dimethylpropan-1-amine;hydrochloride;2,2-Dimethylpropan-1-amine HCl;1-Propanamine, 2,2-dimethyl-, hydrochloride (1:1);1-Propanamine, 2,2-dimethyl-, hydrochloride;neo-Pentylammonium chloride;DTXSID10497548;FLICSJLQAITIQW-UHFFFAOYSA-N;BCP11254;MFCD00136856;AKOS008105337;CS-W019134;2,2-dimethylpropan-1-aminehydrochloride;AC-26539;DS-15596;FT-0689450;EN300-52601;2 pound not2-Dimethylpropan-1-amine hydrochloride;A883314;2,2-Dimethylpropan-1-amine--hydrogen chloride (1/1)

Chemical Property of 2,2-Dimethylpropan-1-amine hydrochloride

Chemical Property:

• Melting Point: 294-296℃
• PSA: 26.02000
• LogP: 2.49350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 123.0814771
• Heavy Atom Count: 7
• Complexity: 33.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2-Dimethylpropan-1-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)CN.Cl

Technology Process of 2,2-Dimethylpropan-1-amine hydrochloride

There total 10 articles about 2,2-Dimethylpropan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl isocyanide (630-18-2) → neopentylamine hydrochloride (15925-18-5)

Guidance literature:

With hydrogenchloride; hydrogen; In propan-1-ol; water; at 60 - 70 ℃; for 18h; under 375.038 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield: 92.0%

2,2-dimethylpropionamide (754-10-9) → neopentylamine hydrochloride (15925-18-5)

Guidance literature:

2,2-dimethylpropionamide; With [(aNHC)KN(SiMe₃)₂]₂; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In toluene; at 40 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;

With water; sodium hydroxide; In diethyl ether; toluene; at 40 ℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique;

With hydrogenchloride; In diethyl ether; water; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1039/c9sc05953a

Reference yield: 50.0%

C14H30NO5P (102095-56-7) → neopentylamine hydrochloride (15925-18-5)

Guidance literature:

With hydrogenchloride; In benzene; for 12h; Ambient temperature;

upstream raw materials:

2,2-dimethylpropionaldehyde oxime

tert-butyl isocyanide

2,2-dimethylpropionamide

C₁₄H₃₀NO₅P

Downstream raw materials:

C₂₁H₃₆N₃O₅P

(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-4-methyl-N-neopentylpentanamide lithium

2,2-dimethylpropyl isocyanate

Refernces

• 1、 Bhunia, Mrinal,Sahoo, Sumeet Ranjan,Das, Arpan,Ahmed, Jasimuddin,Sreejyothi,Mandal, Swadhin K.. "Transition metal-free catalytic reduction of primary amides using an abnormal NHC based potassium complex: Integrating nucleophilicity with Lewis acidic activation". . p. 1848 - 1854. Retrieved 2020/03/03.
• 2、 Das, Hari S.,Das, Shyamal,Dey, Kartick,Singh, Bhagat,Haridasan, Rahul,Das, Arpan,Ahmed, Jasimuddin,Mandal, Swadhin K.. "Primary amides to amines or nitriles: A dual role by a single catalyst". supporting information. p. 11868 - 11871. Retrieved 2019/10/11.