Technology Process of 2-Piperidinone,
6-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-1-[(2S)-2-[(phenylmeth
oxy)methyl]-1-pyrrolidinyl]-, (6R)-
There total 10 articles about 2-Piperidinone,
6-[2-(2-bromo-4,5-dimethoxyphenyl)-2-oxoethyl]-1-[(2S)-2-[(phenylmeth
oxy)methyl]-1-pyrrolidinyl]-, (6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / NaH / tetrahydrofuran; dimethylformamide / 1.) room temp., 30 min, 2.) room temp., 3 h
2: LiAlH4 / tetrahydrofuran / 1.) room temp., 15 min, 2.) reflux, 2 h
3: 2.) Ac2O, NaOAc / 1.) CH2Cl2, room temp., 1 h, 2.) reflux, 1 h
4: 80 percent / LiEt3BH / tetrahydrofuran / 2 h / -78 °C
5: 80 percent / pyridinium p-toluenesulfonate / 3 h / Ambient temperature
6: 70 percent / BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature
With
lithium aluminium tetrahydride; boron trifluoride diethyl etherate; sodium acetate; pyridinium p-toluenesulfonate; acetic anhydride; sodium hydride; lithium triethylborohydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00124a025
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / NaH / tetrahydrofuran; dimethylformamide / 1.) room temp., 30 min, 2.) room temp., 3 h
2: LiAlH4 / tetrahydrofuran / 1.) room temp., 15 min, 2.) reflux, 2 h
3: 2.) Ac2O, NaOAc / 1.) CH2Cl2, room temp., 1 h, 2.) reflux, 1 h
4: 80 percent / LiEt3BH / tetrahydrofuran / 2 h / -78 °C
5: 80 percent / pyridinium p-toluenesulfonate / 3 h / Ambient temperature
6: 70 percent / BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature
With
lithium aluminium tetrahydride; boron trifluoride diethyl etherate; sodium acetate; pyridinium p-toluenesulfonate; acetic anhydride; sodium hydride; lithium triethylborohydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00124a025
