2-Bromo-4-methoxybenzyl Alcohol

Base Information

• Chemical Name: 2-Bromo-4-methoxybenzyl Alcohol
• CAS No.: 163190-79-2
• Molecular Formula: C8H9BrO2
• Molecular Weight: 217.062
• Hs Code.: 2909500090
• DSSTox Substance ID: DTXSID80448446
• Wikidata: Q82267433
• Mol file: 163190-79-2.mol

Synonyms:2-Bromo-4-methoxybenzyl Alcohol;163190-79-2;(2-bromo-4-methoxy-phenyl)methanol;(2-bromo-4-methoxyphenyl)methanol;Benzenemethanol, 2-bromo-4-methoxy-;MFCD11042785;2-Bromo-4-methoxybenzylAlcohol;SCHEMBL7674882;DTXSID80448446;AKOS013400751;AB86628;AS-44069;SY030378;EN300-270011;A903284

Chemical Property of 2-Bromo-4-methoxybenzyl Alcohol

Chemical Property:

• Boiling Point: 299.7±25.0 °C(Predicted)
• PKA: 14.01±0.10(Predicted)
• PSA: 29.46000
• Density: 1.513±0.06 g/cm3(Predicted)
• LogP: 1.95000
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 215.97859
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

98.5% ^*data from raw suppliers

2-Bromo-4-methoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CO)Br

Technology Process of 2-Bromo-4-methoxybenzyl Alcohol

There total 1 articles about 2-Bromo-4-methoxybenzyl Alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-4-methoxybenzaldehyde (43192-31-0) → (2-bromo-4-methoxyphenyl)methanol (163190-79-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 1.5h;

DOI:10.1039/b614999e

Reference yield: 84.0%

(2-bromo-4-methoxyphenyl)methanol (163190-79-2) + methyl iodide (74-88-4) → 2-bromo-4-methoxy-1-(methoxymethyl)benzene (1032842-37-7)

Guidance literature:

(2-bromo-4-methoxyphenyl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2h;

Reference yield:

(2-bromo-4-methoxyphenyl)methanol (163190-79-2) → 2-bromo-1-(bromomethyl)-4-methoxybenzene (54788-18-0)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 0 - 20 ℃;

DOI:10.1039/b614999e

upstream raw materials:

2-bromo-4-methoxybenzaldehyde

Downstream raw materials:

2-bromo-1-(bromomethyl)-4-methoxybenzene

1-benzyl-2-ethynyl-4-methoxybenzene

2-bromo-4-methoxy-1-(methoxymethyl)benzene

Refernces

• 1、 Tan, Qiuyuan,Yang, Zhao,Jiang, Dan,Cheng, Yuegang,Yang, Jiao,Xi, Song,Zhang, Min. "Copper-Catalyzed Aerobic Oxidative Cyclization Cascade to Construct Bridged Skeletons: Total Synthesis of (?)-Suaveoline". supporting information. p. 6420 - 6424. Retrieved 2019/04/13.
• 2、 Bower, John F.,Szeto, Peter,Gallagher, Timothy. "Cyclic sulfamidates as versatile lactam precursors. An evaluation of synthetic strategies towards (-)-aphanorphine". . p. 143 - 150. Retrieved 2008/03/28.