2-(1-Methyl-1H-indol-3-yl)-2-oxoacetaMide

Base Information

• Chemical Name: 2-(1-Methyl-1H-indol-3-yl)-2-oxoacetaMide
• CAS No.: 16382-39-1
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• Hs Code.: 2924199090
• Mol file: 16382-39-1.mol

Synonyms:2-(1-methylindol-3-yl)-2-oxoacetamide;

Chemical Property of 2-(1-Methyl-1H-indol-3-yl)-2-oxoacetaMide

Chemical Property:

• Melting Point: 128-129 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 422.1±37.0 °C(Predicted)
• PKA: 12.82±0.50(Predicted)
• PSA: 65.09000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 1.54660
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

2-(1-Methyl-1H-indol-3-yl)-2-oxoacetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1-Methyl-1H-indol-3-yl)-2-oxoacetaMide

There total 8 articles about 2-(1-Methyl-1H-indol-3-yl)-2-oxoacetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-methylindole-3-glyoxylyl chloride (16382-38-0) → 2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide (16382-39-1)

Guidance literature:

With ammonium hydroxide; at 0 ℃; for 1h;

DOI:10.1016/j.bmcl.2010.11.026

Reference yield: 73.0%

N-methyl-3-acetylindole (19012-02-3) → 2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide (16382-39-1)

Guidance literature:

With iodine; formamidine hydrochloride; In dimethyl sulfoxide; at 110 ℃; for 11h;

DOI:10.1039/c4ob02591a

Reference yield: 58.0%

ethyl 2-(1-methyl-1H-indol-3-yl)acetimidate hydrochloride → 2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide (16382-39-1)

Guidance literature:

With oxygen; copper diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 10h; under 760.051 Torr;

DOI:10.1021/acs.joc.6b01262

upstream raw materials:

indole-3-glyoxylamide

methyl iodide

1-methylindole-3-glyoxylyl chloride

1-methylindole

Downstream raw materials:

3-(1-methyl-3-indolyl)-4-phenyl-1H-pyrrole-2,5-dione

3-(4-methoxyphenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Refernces

• 1、 Veale, Clinton G.L.. "A new synthesis of versatile indolyl-3-carbonylnitriles". . p. 5287 - 5290. Retrieved 2015/08/26.
• 2、 Wang, Min,Gao, Mingzhang,Miller, Kathy D.,Sledge, George W.,Hutchins, Gary D.,Zheng, Qi-Huang. "The first synthesis of [11C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3)". experimental part. p. 245 - 249. Retrieved 2011/02/27.