2-benzylsulfonylacetic acid

Base Information

• Chemical Name: 2-benzylsulfonylacetic acid
• CAS No.: 28203-59-0
• Molecular Formula: C9H10O4S
• Molecular Weight: 214.242
• Hs Code.: 2916399090
• Mol file: 28203-59-0.mol

Synonyms:Aceticacid, (benzylsulfonyl)- (6CI,7CI,8CI);Acetic acid, [(phenylmethyl)sulfonyl]-(9CI);Benzylsulfonylacetic acid;NSC 207839;NSC 77402;

Chemical Property of 2-benzylsulfonylacetic acid

Chemical Property:

• Vapor Pressure: 2.01E-10mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 490.2 °C at 760 mmHg
• Flash Point: 250.3 °C
• PSA: 79.82000
• Density: 1.387g/cm³
• LogP: 1.76680

Purity/Quality:

98%min ^*data from raw suppliers

(benzylsulfonyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzylsulfonylacetic acid

There total 13 articles about 2-benzylsulfonylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl 2,2,2-trifluoroethyl sulfonate (111128-36-0) → (benzylsulfonyl)acetic acid (28203-59-0)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 0.5h; Ambient temperature;

DOI:10.1021/jo9610366

Reference yield: 90.0%

S-benzylmercaptoacetic acid (103-46-8) → (benzylsulfonyl)acetic acid (28203-59-0)

Guidance literature:

With dihydrogen peroxide; In acetic acid;

Reference yield: 15.0%

benzyl carbethoxymethyl sulfone (29771-81-1) → (benzylsulfonyl)acetic acid (28203-59-0) + 1,1-Dioxo-2-phenyl-1λ6-thietan-3-one (31462-44-9)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In benzene; at 100 ℃; for 12h;

upstream raw materials:

S-benzylmercaptoacetic acid

benzyl carbethoxymethyl sulfone

sodium monochloroacetic acid

phenylmethanethiol

Downstream raw materials:

benzyl-methyl sulfone

1-Methyl-4-((E)-2-phenylmethanesulfonyl-vinyl)-benzene

2,4-Dichloro-1-((E)-2-phenylmethanesulfonyl-vinyl)-benzene

1,2-Dimethoxy-4-((E)-2-phenylmethanesulfonyl-vinyl)-benzene

Refernces

• 1、 Boschmann, Erwin,Miller, Roger D.. "Influence of sulfur groups on carboxylic acid strengths". . p. 2617 - 2619. Retrieved 2018/04/30.
• 2、 Zhou, Nan,Feng, Tian,Shen, Xin,Cui, Jiahui,Wu, Rangxin,Wang, Libin,Wang, Siwang,Zhang, Shengyong,Chen, Hui. "Synthesis, characterization, and radioprotective activity of α,β-unsaturated aryl sulfone analogs and their Tempol conjugates". supporting information. p. 1063 - 1068. Retrieved 2017/07/12.