Benzenepropanol, 2-fluoro-, methanesulfonate

Base Information

• Chemical Name: Benzenepropanol, 2-fluoro-, methanesulfonate
• CAS No.: 166949-93-5
• Molecular Formula: C10H13FO3S
• Molecular Weight: 232.276
• Mol file: 166949-93-5.mol

Synonyms:Benzenepropanol, 2-fluoro-, methanesulfonate

Chemical Property of Benzenepropanol, 2-fluoro-, methanesulfonate

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanol, 2-fluoro-, methanesulfonate

There total 3 articles about Benzenepropanol, 2-fluoro-, methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-(2-fluorophenyl)propan-1-ol (76727-24-7) + methanesulfonyl chloride (124-63-0) → 1-[3-(methylsulfonyloxy)propyl]-2-fluorobenzene (166949-93-5)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

3-(2-fluorophenyl)propionic acid (1643-26-1) → 1-[3-(methylsulfonyloxy)propyl]-2-fluorobenzene (166949-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether

2: Et₃N / CH₂Cl₂

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jo972065z

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → 1-[3-(methylsulfonyloxy)propyl]-2-fluorobenzene (166949-93-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / Py, piperidine

2: 89 percent / HI-H₂O, red P

3: LiAlH₄ / diethyl ether

4: Et₃N / CH₂Cl₂

With piperidine; pyridine; phosphorus; lithium aluminium tetrahydride; hydrogen iodide; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/jo972065z

upstream raw materials:

3-(2-fluorophenyl)propan-1-ol

methanesulfonyl chloride

3-(2-fluorophenyl)propionic acid

2-Fluorobenzaldehyde

Downstream raw materials:

2-fluoro-1-(3-iodopropyl)benzene

1-fluoro-2-propylbenzene

(+/-)-Hydroxy-phenyl-(indanyl-⁽⁴⁾)-methan

4-bromo-2,3-dihydro-1H-indene

Refernces

• 1、 -. "Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation". . . Retrieved 2008/06/13.