Cyclohexanecarbohydrazide

Base Information

• Chemical Name: Cyclohexanecarbohydrazide
• CAS No.: 38941-47-8
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.201
• Hs Code.: 2928000090
• European Community (EC) Number: 673-594-8
• NSC Number: 45908
• DSSTox Substance ID: DTXSID20286460
• Nikkaji Number: J1.218.161B
• Wikidata: Q82022194
• Mol file: 38941-47-8.mol

Synonyms:Cyclohexanecarbohydrazide;38941-47-8;Cyclohexanecarboxylic acid hydrazide;MFCD01357897;Cyclohexanecarboxylic acid, hydrazide;CyclohexCON2;cyclohexanohydrazide;Cyclohexane carboxylic acid hydrazide;CYCLOHEXANECARBOXYLICACIDHYDRAZIDE;cyclohexane-carbohydrazide;Cyclohexanecarbohydrazide #;Oprea1_203627;Oprea1_796383;SCHEMBL293980;DTXSID20286460;HMS1783M04;NSC45908;BBL014284;NSC 45908;NSC-45908;STK017897;AKOS000194931;BD-0312;AMY202100078;BB 0240946;CS-0094661;FT-0624187;EN300-06614;D82260;A824340;Z56930714

Chemical Property of Cyclohexanecarbohydrazide

Chemical Property:

• Vapor Pressure: 0.000572mmHg at 25°C
• Melting Point: 153 °C
• Refractive Index: 1.5
• Boiling Point: 311.2 °C at 760 mmHg
• PKA: 13.62±0.20(Predicted)
• Flash Point: 142 °C
• PSA: 55.12000
• Density: 1.063 g/cm³
• LogP: 1.64780
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 142.110613074
• Heavy Atom Count: 10
• Complexity: 119

Purity/Quality:

98%min ^*data from raw suppliers

Cyclohexanecarbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C(=O)NN

Technology Process of Cyclohexanecarbohydrazide

There total 6 articles about Cyclohexanecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl cyclohexanecarboxylate (3289-28-9) → cyclohexanecarbohydrazide (38941-47-8)

Guidance literature:

With hydrazine hydrate; at 20 ℃; Reflux;

DOI:10.1021/jm701562x

Reference yield: 90.1%

Cyclohexanecarboxylic acid (98-89-5) → cyclohexanecarbohydrazide (38941-47-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/jhet.2418

Reference yield: 85.0%

methyl cyclohexylcarboxylate (4630-82-4) → cyclohexanecarbohydrazide (38941-47-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 20h; Reflux;

DOI:10.1021/acs.jmedchem.5b00608

upstream raw materials:

ethyl cyclohexanecarboxylate

benzoic acid hydrazide

methyl cyclohexylcarboxylate

Cyclohexanecarboxylic acid

Downstream raw materials:

3-cyclohexyl-5-phenyl-1H-[1,2,4]triazole

3-cyclohexyl-5-phenyl-1H-[1,2,4]triazole

5-cyclohexyl-1,3,4-oxadiazol-2-amine

cyclohexanecarboxylic acid (1-methylethylidene)hydrazide

Refernces

• 1、 Wu, Dehua,Song, Jintong,Qu, Lang,Zhou, Weilan,Wang, Lei,Zhou, Xiangge,Xiang, Haifeng. "Ultralow-Molecular-Weight Stimuli-Responsive and Multifunctional Supramolecular Gels Based on Monomers and Trimers of Hydrazides". supporting information. p. 3370 - 3378. Retrieved 2020/10/02.
• 2、 Karabanovich, Galina,Zemanová, Júlia,Smutny, Tomá?,Székely, Rita,?arkan, Michal,Centárová, Ivana,Vocat, Anthony,Pávková, Ivona,?onka, Patrik,Něme?ek, Jan,Stola?íková, Ji?ina,Vejsová, Marcela,Vávrová, Kate?ina,Klime?ová, Věra,Hrabálek, Alexandr,Pávek, Petr,Cole, Stewart T.,Miku?ová, Katarína,Roh, Jaroslav. "Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis". supporting information. p. 2362 - 2380. Retrieved 2016/04/09.