Technology Process of 12-oxo-5E,8E,10Z-heptadecatrienoic acid
There total 10 articles about 12-oxo-5E,8E,10Z-heptadecatrienoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1H-imidazole
2: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
3: tetrabutyl ammonium fluoride
4: triethylamine; dmap / dichloromethane
5: sodium iodide / acetone
6: acetonitrile
7: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
8: tetrabutyl ammonium fluoride
9: lithium hydroxide / tetrahydrofuran; water
10: Dess-Martin periodane
With
1H-imidazole; dmap; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; Dess-Martin periodane; triethylamine; sodium iodide; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
2: |Suzuki-Miyaura Coupling / 7: |Wittig Olefination;
DOI:10.1055/s-0033-1338961
- Guidance literature:
-
Multi-step reaction with 9 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
2: tetrabutyl ammonium fluoride
3: triethylamine; dmap / dichloromethane
4: sodium iodide / acetone
5: acetonitrile
6: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
7: tetrabutyl ammonium fluoride
8: lithium hydroxide / tetrahydrofuran; water
9: Dess-Martin periodane
With
dmap; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; Dess-Martin periodane; triethylamine; sodium iodide; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
1: |Suzuki-Miyaura Coupling / 6: |Wittig Olefination;
DOI:10.1055/s-0033-1338961
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrabutyl ammonium fluoride
2: triethylamine; dmap / dichloromethane
3: sodium iodide / acetone
4: acetonitrile
5: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
6: tetrabutyl ammonium fluoride
7: lithium hydroxide / tetrahydrofuran; water
8: Dess-Martin periodane
With
dmap; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; Dess-Martin periodane; triethylamine; sodium iodide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
5: |Wittig Olefination;
DOI:10.1055/s-0033-1338961