Tri-m-tolylphosphine

Base Information

• Chemical Name: Tri-m-tolylphosphine
• CAS No.: 6224-63-1
• Molecular Formula: C21H21P
• Molecular Weight: 304.371
• Hs Code.: HOSPHINE PRODUCT IDENTIFICATION
• European Community (EC) Number: 228-312-4
• UNII: SAQ9Z5ZSC8
• DSSTox Substance ID: DTXSID3064146
• Nikkaji Number: J35.499F
• Wikidata: Q72515277
• Mol file: 6224-63-1.mol

Synonyms:Tri-m-tolylphosphine;6224-63-1;Tri(m-tolyl)phosphine;Tris(3-methylphenyl)phosphine;Phosphine, tris(3-methylphenyl)-;Tris(m-tolyl)phosphine;Phosphine, tri-m-tolyl-;tris(3-methylphenyl)phosphane;Tris(3-tolyl)phosphine;SAQ9Z5ZSC8;C21H21P;EINECS 228-312-4;MFCD00008532;TRI-M-TOLYL-PHOSPHANE;trim-tolylphosphine;tri-m-tolyl phosphine;Phosphorus tri-m-tolyl;tri(3-Tolyl)phosphine;UNII-SAQ9Z5ZSC8;SCHEMBL49786;tri-(3-Methylphenyl)phosphine;DTXSID3064146;TRIS(3-TOLUENE)PHOSPHINE;LFNXCUNDYSYVJY-UHFFFAOYSA-;AMY39392;BCP22567;AKOS004908999;CS-W012100;GC10062;AS-10668;SY035721;FT-0636030;T1025;TRI-M-TOLYLPHOSPHINE;TRIS(3-METHYLPHENYL)PHOSPHANE;TRIS(3-METHYLPHENYL)PHOSPHINE;TRIS(3-TOLYL)PHOSPHINE;TRIS(M-TOLYL)PHOSPHINE

Chemical Property of Tri-m-tolylphosphine

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 5.65E-07mmHg at 25°C
• Melting Point: 97-99 °C(lit.)
• Boiling Point: 423.1 °C at 760 mmHg
• Flash Point: 221.6 °C
• PSA: 13.59000
• LogP: 4.37000
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 3
• Exact Mass: 304.138087668
• Heavy Atom Count: 22
• Complexity: 287

Purity/Quality:

99% ^*data from raw suppliers

Tri-m-tolylphosphine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-38-37-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC=C1)P(C2=CC=CC(=C2)C)C3=CC=CC(=C3)C
• Uses: suzuki reaction Tri-m-tolylphosphine acts as a reagent for the preparation, crystal structure, multinuclear NMR, antitumor activity, photolysis of silver methylxanthate complexes against human adrenocarcinoma breast cancer cells.

Technology Process of Tri-m-tolylphosphine

There total 14 articles about Tri-m-tolylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tri(m-tolyl)phosphine oxide (6151-88-8) → tri(m-tolyl)phosphine (6224-63-1)

Guidance literature:

With oxalyl dichloride; hydrogen; In chloroform-d1; at 130 ℃; for 18h; under 60006 Torr; Reagent/catalyst;

DOI:10.1002/anie.201809275

Reference yield: 92.0%

→ tri(m-tolyl)phosphine (6224-63-1)

Guidance literature:

Reference yield: 75.0%

m-tolylmagnesium bromide (28987-79-3) → tri(m-tolyl)phosphine (6224-63-1)

Guidance literature:

With phosphorus trichloride; In diethyl ether;

DOI:10.1021/ja00293a038

upstream raw materials:

m-tolylmagnesium bromide

1-chloro-3-methylbenzene

meta-bromotoluene

m-tolylzinc(II) bromide

Downstream raw materials:

C₂₁H₂₁OP*C₇H₉NO₂S

[(η5-C5H5)Ru(P(3-CH3-C6H4)3)2Cl]

(CO)3NiP(C₆H₄CH₃-m)3

trans-Fe(CO)3{P(OPh)3}{P(m-C₆H₄CH₃)3}

Refernces

• 1、 -. "Synthesis method of phosphine (III) compound". Paragraph 0020. . Retrieved 2021/11/27.
• 2、 García-Domínguez, Andrés,Gonzalez, Jorge A.,Leach, Andrew G.,Lloyd-Jones, Guy C.,Nichol, Gary S.,Taylor, Nicholas P.. "A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics". supporting information. . Retrieved 2022/01/04.