Chemical Property of VITAMIN K1
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Chemical Property:
- Vapor Pressure:5.37E-12mmHg at 25°C
- Melting Point:−20 °C(lit.)
- Refractive Index:n20/D 1.527(lit.)
- Boiling Point:546.4°Cat760mmHg
- Flash Point:200.4°C
- PSA：34.14000
- Density:0.963g/cm3
- LogP:9.15760
- Storage Temp.:2-8°C
- Purity/Quality:
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99% *data from raw suppliers
VITAMIN K 95.00% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Biological Functions
Both vitamins K3 and K4 may
produce hyperbilirubinemia and kernicterus in neonates as well as hemolysis in neonates and
glucose-6-phosphate–deficient patients. In fact, the only advantage of vitamins K3 and K4 over
vitamin K1 is that whereas absorption of vitamin K1 requires the presence of bile, absorption of
vitamins K3 and K4 does not, because they are absorbed via a passive process directly from the
intestine. This may be a slight advantage for patients with cholestasis or severe pancreatic
dysfunction. Only vitamin K1, however, is appropriate therapy for bleeding associated with warfarin
and superwarfarin anticoagulation. Vitamin K2 is not used therapeutically.
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Clinical Use
Vitamin K1 (phytonadione, Mephyton) is
the form of vitamin K most often used therapeutically. Vitamin K1 is safe for use in infants, pregnant
women, and patients with glucose-6-phosphate deficiency.
