triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester

Base Information

• Chemical Name: triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester
• CAS No.: 132062-52-3
• Molecular Formula: C₁₂H₁₇N₂O₁₁P₃
• Molecular Weight: 458.195
• Mol file: 132062-52-3.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine,triphosphoric acid deriv.

Chemical Property of triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester

Chemical Property:

• Vapor Pressure: 1.14E-23mmHg at 25°C
• Boiling Point: 750.6°Cat760mmHg
• Flash Point: 407.8°C
• Density: 2.04g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester

There total 5 articles about triphosphoric acid, mono[[(2S,5R)-tetrahydro-5-(1H-pyrrolo[2,3-b]pyridin-1-yl)-2-furanyl]methyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H-pyrrolo<2,3-b>pyridine (124481-39-6) → C12H17N2O11P3 (132062-52-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 58 percent / (i-Pr)2EtN / pyridine / 4 h / Ambient temperature

2: 53 percent / 4-(dimethylamino)pyridine / acetonitrile / 48 h / Ambient temperature

3: 93 percent / Bu₃SnH, AIBN / toluene / 5 h / 80 °C

4: 90 percent / 80percent aq. AcOH / 3 h / Ambient temperature

5: 1) POCl₃; 2) (Bu₃NH)4P₂O₇, Bu₃N / 1) PO(OMe)3, 4 deg C, 3 h; 2) DMF, 0 deg C, 1 min

With dmap; tributyl-amine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tri(n-butyl)ammonium pyrophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In pyridine; toluene; acetonitrile;

DOI:10.1002/hlca.19910740514

Reference yield:

1-<2-Deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl>-1-pyrrolo<2,3-b>pyridine (134440-30-5) → C12H17N2O11P3 (132062-52-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 53 percent / 4-(dimethylamino)pyridine / acetonitrile / 48 h / Ambient temperature

2: 93 percent / Bu₃SnH, AIBN / toluene / 5 h / 80 °C

3: 90 percent / 80percent aq. AcOH / 3 h / Ambient temperature

4: 1) POCl₃; 2) (Bu₃NH)4P₂O₇, Bu₃N / 1) PO(OMe)3, 4 deg C, 3 h; 2) DMF, 0 deg C, 1 min

With dmap; tributyl-amine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tri(n-butyl)ammonium pyrophosphate; acetic acid; trichlorophosphate; In toluene; acetonitrile;

DOI:10.1002/hlca.19910740514

Reference yield:

1--5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl>-1H-pyrrolo<2,3-b>pyridine (134440-31-6) → C12H17N2O11P3 (132062-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / Bu₃SnH, AIBN / toluene / 5 h / 80 °C

2: 90 percent / 80percent aq. AcOH / 3 h / Ambient temperature

3: 1) POCl₃; 2) (Bu₃NH)4P₂O₇, Bu₃N / 1) PO(OMe)3, 4 deg C, 3 h; 2) DMF, 0 deg C, 1 min

With tributyl-amine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tri(n-butyl)ammonium pyrophosphate; acetic acid; trichlorophosphate; In toluene;

DOI:10.1002/hlca.19910740514

upstream raw materials:

1-(2,3-Dideoxy-β-D-glycero-pentofuranosyl)-1H-pyrrolo<2,3-b>pyridine

1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H-pyrrolo<2,3-b>pyridine

1-<2,3-Dideoxy-5-O-(triphenylmethyl)-β-D-glycero-pentofuranosyl>-1H-pyrrolo<2,3-b>pyridine

1-<2-Deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl>-1-pyrrolo<2,3-b>pyridine

Refernces