Cinepazide

Base Information

• Chemical Name: Cinepazide
• CAS No.: 23887-46-9
• Molecular Formula: C22H31N3O5
• Molecular Weight: 417.505
• European Community (EC) Number: 245-928-9
• UNII: 67Y4P5C84X
• DSSTox Substance ID: DTXSID901112229
• Nikkaji Number: J257.431D,J20.276B
• Wikipedia: Cinepazide
• Wikidata: Q5120864
• NCI Thesaurus Code: C91001
• Metabolomics Workbench ID: 153169
• ChEMBL ID: CHEMBL1874750
• Mol file: 23887-46-9.mol

Synonyms:1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine;1-((1-pyrrolidynylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine maleate;67350-MD;cinepazide;cinepazide maleate;MD-67350 free base;Vasodistal

Chemical Property of Cinepazide

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 3.65E-16mmHg at 25°C
• Melting Point: 170 - 175oC
• Refractive Index: 1.574
• Boiling Point: 637.8 °C at 760 mmHg
• PKA: 5.22±0.10(Predicted)
• Flash Point: 339.5 °C
• PSA: 71.55000
• Density: 1.2 g/cm³
• LogP: 1.30590
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 417.22637110
• Heavy Atom Count: 30
• Complexity: 586

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cinepazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3
• Isomeric SMILES: COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCN(CC2)CC(=O)N3CCCC3
• Recent ClinicalTrials: Methanesulfonic Acid Cinepazide Injection for Treatment of Acute Cerebral Infarction
• Uses: Cinepazide is an injection in the treatment of acute myocardial infarction and its effect on serum inflammatory factors.

Technology Process of Cinepazide

There total 2 articles about Cinepazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-[(pyrrolidine-1-carbonyl)methyl]piperazine (39890-45-4) + 3',4',5'-trimethoxycinnamoyl chloride (10263-19-1) → cinepazide (23887-46-9,88197-48-2,88197-50-6)

Guidance literature:

With triethylamine; In benzene; Heating;

DOI:10.1248/cpb.36.3948

Reference yield:

→ cinepazide (23887-46-9,88197-48-2,88197-50-6)

Guidance literature:

3,4,5-Trimethoxyzimtsaeurechlorid, /BRN= 880915/;

upstream raw materials:

1-[(pyrrolidine-1-carbonyl)methyl]piperazine

3',4',5'-trimethoxycinnamoyl chloride

Refernces