Technology Process of 2,4-Thiazolidinedione,
5-[[4-[(5-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]phen
yl]methyl]-3-(triphenylmethyl)-
There total 6 articles about 2,4-Thiazolidinedione,
5-[[4-[(5-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]phen
yl]methyl]-3-(triphenylmethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tributylphosphine; 1,1'-azodicarbonyl-dipiperidine;
In
toluene;
at 20 ℃;
for 4h;
DOI:10.1021/jm990522t
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / Na2CO3 / ethanol / 8 h / 20 °C
2: 91 percent / methanol / 3 h / 20 °C
3: 92 percent / H2 / 10percent Pd/C / dioxane / 5 h / 80 °C
4: 22 percent / toluene / 4 h / Heating
5: 84 percent / azodicarbonyldipieridine; Bu3P / toluene / 4 h / 20 °C
With
tributylphosphine; hydrogen; sodium carbonate; 1,1'-azodicarbonyl-dipiperidine;
10percent Pd/C;
In
1,4-dioxane; methanol; ethanol; toluene;
1: Amination / 2: Methoxylation / 3: Catalytic hydrogenation / 4: Cyclization / 5: Mitsunobu reaction;
DOI:10.1021/jm990522t
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / methanol / 3 h / 20 °C
2: 92 percent / H2 / 10percent Pd/C / dioxane / 5 h / 80 °C
3: 22 percent / toluene / 4 h / Heating
4: 84 percent / azodicarbonyldipieridine; Bu3P / toluene / 4 h / 20 °C
With
tributylphosphine; hydrogen; 1,1'-azodicarbonyl-dipiperidine;
10percent Pd/C;
In
1,4-dioxane; methanol; toluene;
1: Methoxylation / 2: Catalytic hydrogenation / 3: Cyclization / 4: Mitsunobu reaction;
DOI:10.1021/jm990522t