1,2,3,4-TETRAHYDRO-1-ACETYLQUINOLINE

Base Information

• Chemical Name: 1,2,3,4-TETRAHYDRO-1-ACETYLQUINOLINE
• CAS No.: 4169-19-1
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Hs Code.: 2933499090
• Mol file: 4169-19-1.mol

Synonyms:Acetyltetrahydroquinoline;Cuzol A;N-Acetyl-1,2,3,4-tetrahydroquinoline;NSC 406746;1-Acetyl-1,2,3,4-tetrahydroquinoline;Quinoline,1-acetyl-1,2,3,4-tetrahydro- (6CI,7CI,8CI,9CI);

Chemical Property of 1,2,3,4-TETRAHYDRO-1-ACETYLQUINOLINE

Chemical Property:

• Vapor Pressure: 1.05E-05mmHg at 25°C
• Refractive Index: 1.558
• Boiling Point: 371.1 °C at 760 mmHg
• Flash Point: 181.1 °C
• PSA: 20.31000
• Density: 1.105 g/cm³
• LogP: 2.05070

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Acetyl-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-TETRAHYDRO-1-ACETYLQUINOLINE

There total 20 articles about 1,2,3,4-TETRAHYDRO-1-ACETYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + acetic anhydride (108-24-7) → 1-acetyl-1,2,3,4-tetrahydroquinoline (4169-19-1)

Guidance literature:

In dichloromethane; at 0 - 25 ℃;

Reference yield: 93.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + cycl-isopropylidene malonate (2033-24-1) → 1-acetyl-1,2,3,4-tetrahydroquinoline (4169-19-1)

Guidance literature:

In toluene; for 12h; Inert atmosphere; Reflux;

DOI:10.1039/d0gc03731a

Reference yield: 89.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + acetyl chloride (75-36-5) → 1-acetyl-1,2,3,4-tetrahydroquinoline (4169-19-1)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 25 ℃; for 1h;

DOI:10.1002/ejoc.201001459

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

acetic anhydride

decahydroquinoline

acetic acid

Downstream raw materials:

1-benzyl-6-methoxy-1,2,3,4-tetrahydroquinoline

1-(8-(3-fluorophenyl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

1-(8-(4-fluorophenyl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

1-(8-(4-phenoxyphenyl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

Refernces

• 1、 Ghosh, Santanu,Purkait, Anisha,Jana, Chandan K.. "Environmentally benign decarboxylative: N-, O-, and S-Acetylations and acylations". supporting information. p. 8721 - 8727. Retrieved 2020/12/30.
• 2、 Bronner, Sarah M.,Murray, Jeremy,Romero, F. Anthony,Lai, Kwong Wah,Tsui, Vickie,Cyr, Patrick,Beresini, Maureen H.,De Leon Boenig, Gladys,Chen, Zhongguo,Choo, Edna F.,Clark, Kevin R.,Crawford, Terry D.,Jayaram, Hariharan,Kaufman, Susan,Li, Ruina,Li, Yingjie,Liao, Jiangpeng,Liang, Xiaorong,Liu, Wenfeng,Ly, Justin,Maher, Jonathan,Wai, John,Wang, Fei,Zheng, Aijun,Zhu, Xiaoyu,Magnuson, Steven. "A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors". . p. 10151 - 10171. Retrieved 2018/01/10.