Amizoptene

Base Information

• Chemical Name: Amizoptene
• CAS No.: 57559-72-5
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.247
• Mol file: 57559-72-5.mol

Synonyms:4-amino-1,2-benzocycloheptene;4-Amino-1,2-benzo-cyclohepten-(1);rac.-4-Amino-1,2-benzo-cyclohepten-(1);6-Amino-6,7,8,9-tetrahydro-5H-benzocyclohepten;6,7,8,9-Tetrahydro-5H-benzocyclohepten-6-ylamine;6,7,8,9-Tetrahydro-5H-benzocyclohepten-6-yl Amine;(+)-4-Amino-1,2-benzo-cyclohepten-(1);

Chemical Property of Amizoptene

Chemical Property:

• PSA: 26.02000
• LogP: 2.59300

Purity/Quality:

6,7,8,9-Tetrahydro-5H-benzo[7]annulen-6-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Amizoptene

There total 9 articles about Amizoptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1,2-benzo-1,3-cycloheptadiene (7125-62-4) → (+)-4-Amino-1,2-benzo-cyclohepten-(1) (57559-72-5)

Guidance literature:

With benzene-1,3-dicarbonitrile; 1,2,4-triphenylbenzene; ammonia; In water; acetonitrile; at 20 ℃; Irradiation;

DOI:10.1021/jo030053+

Reference yield:

5,6,8,9-tetrahydrobenzo[7]annulen-7-one (37949-03-4) → (+)-4-Amino-1,2-benzo-cyclohepten-(1) (57559-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / Na, n-butyl nitrite / ethanol; diethyl ether

2: 1.) H₂, 2.) H₂, HClO₄ / 10percent Pd/C / 1.) glacial AcOH, RT, 50 psig, 2.) glacial AcOH, 70 deg C, 52 psig

With perchloric acid; n-Butyl nitrite; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol;

DOI:10.1021/jm00181a009

Reference yield:

6-oximino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one (105124-23-0) → (+)-4-Amino-1,2-benzo-cyclohepten-(1) (57559-72-5)

Guidance literature:

With perchloric acid; hydrogen; palladium on activated charcoal; Multistep reaction; 1.) glacial AcOH, RT, 50 psig, 2.) glacial AcOH, 70 deg C, 52 psig;

DOI:10.1021/jm00181a009

upstream raw materials:

5,7,8,9-tetrahydro-benzocyclohepten-6-one oxime

6-oximino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one

5,7,8,9-tetrahydrobenzo[7]annulen-6-one

1,2-benzo-1,3-cycloheptadiene

Refernces

• 1、 -. "Acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenyl amines and their use as pharmaceutical agents". . . Retrieved 2008/06/13.