N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE

Base Information

• Chemical Name: N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE
• CAS No.: 3695-02-1
• Molecular Formula: C15H17NO2S
• Molecular Weight: 275.371
• Hs Code.: 2935009090
• Mol file: 3695-02-1.mol

Synonyms:N-benzyl-N-methyl-toluene-4-sulfonamide;p-Toluolsulfonyl-methylbenzylamin;N-Benzyl-N-methyl-p-toluenesulfonamide;p-Toluolsulfonsaeure-methylbenzylamid;N-benzyl-N-methyl-4-methylbenzenesulfonamide;N-BENZYL-N,4-DIMETHYL-BENZENESULFONAMIDE;N-Benzyl-N-methyl-toluol-4-sulfonamid;

Chemical Property of N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 3.15E-07mmHg at 25°C
• Boiling Point: 419°Cat760mmHg
• Flash Point: 207.2°C
• PSA: 45.76000
• Density: 1.187g/cm³
• LogP: 3.89650

Purity/Quality:

99%min ^*data from raw suppliers

N-BENZYL-4,N-DIMETHYL-BENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE

There total 34 articles about N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trifluoroacetic acid-methyl ester (431-47-0) + N-benzyl-p-toluenesulfonamide (1576-37-0) → N-benzyl-N-methyl-p-toluenesulfonamide (3695-02-1)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield: 100.0%

benzyl alcohol (100-51-6,185532-71-2) + N-methyl-p-toluenesulfonylamide (640-61-9) → N-benzyl-N-methyl-p-toluenesulfonamide (3695-02-1)

Guidance literature:

With cyanomethylenetributyl-phosphorane; In benzene; at 100 ℃; for 24h;

DOI:10.1016/S0040-4039(00)73326-0

Reference yield: 99.0%

benzyl 2-(2-phenylethynyl)benzoate + N-methyl-p-toluenesulfonylamide (640-61-9) → N-benzyl-N-methyl-p-toluenesulfonamide (3695-02-1)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2008.12.033

upstream raw materials:

N-benzyl-p-toluenesulfonamide

methyl iodide

p-toluene sulfinic acid

N-benzyl-N-chloromethylamine

Downstream raw materials:

benzyl-methyl-amine

N-Benzylidenemethylamine

N-benzylidenemethylamine

toluene

Refernces

• 1、 -. "Method for selective N-methylation of secondary amide". Paragraph 0011. . Retrieved 2019/03/08.
• 2、 Zhang, Feng,Zheng, Danqing,Lai, Lifang,Cheng, Jiang,Sun, Jiangtao,Wu, Jie. "Synthesis of aromatic sulfonamides through a copper-catalyzed coupling of aryldiazonium tetrafluoroborates, DABCO·(SO2)2, and N-Chloroamines". supporting information. p. 1167 - 1170. Retrieved 2018/02/23.